Apolipoprotein E/ApoE Antibody (3D12)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC, IHC-Fr
Clone
3D12
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

Apolipoprotein E/ApoE Antibody (3D12) Summary

Immunogen
The antibody reacts with very low density lipoproteins (VLDL) of human plasma.This antibody recognizes all alleles of APO-E.
Specificity
The antibody reacts with very low density lipoproteins (VLDL) of human plasma. It is specific for human apo-E. No cross reactions with other human plasma proteins were detected. This antibody reacts as well with LDL as with VLDL. This antibody recognizes all alleles of APO-E.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
APOE
Purity
Sodium sulfate precipitation
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:100
Application Notes
In combination with other mabs for detection of VLDL in plasma, and for the specific detection of apo-E. The antibody is also useful for detection of apo-E in tissue sections.The antibody can be used in ELISA techniques and in immunohisto-chemistry on frozen sections and possibly on paraffin embedded tissues. For application on paraffin embedded tissues an optimal dilution has to be determined within each laboratory. For depletion experiments the antibody should be used in a solid phase system.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
No Preservative
Concentration
LYOPH
Purity
Sodium sulfate precipitation
Reconstitution Instructions
Reconstitute with 1 ml sterilized water and with preservative if preferred.

Alternate Names for Apolipoprotein E/ApoE Antibody (3D12)

  • APOE
  • Apo-E
  • Apolipoprotein E
  • apolipoprotein E3
  • late onset)
  • MGC1571

Background

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol APOE
Entrez