APH1A Antibody

Product Discontinued

APH1A Antibody Summary

• Immunogen: Peptide with sequence C-HVTDRSDARLQYG corresponding to internal region according to NP_001071096.1, NP_057106.2.
• Epitope: HVTDRSDARLQYG
• Specificity: This antibody is expected to recognize isoform 1 (NP_001071096.1) and isoform 2 (NP_057106.2).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: APH1A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
  • Western Blot 0.05 - 0.1 ug/ml
• Application Notes: WB: Approx. 26 kDa band observed in human brain (cerebral cortex) lysates (calculated MW of 26.8 kDa band according to NP_057106.2).

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Porcine, Bovine.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for APH1A Antibody

• 6530402N02Rik
• anterior pharynx defective 1 homolog A (C. elegans)
• APH-1
• APH1A
• APH-1A
• aph-1alpha
• CGI-78
• gamma-secretase subunit APH-1A
• Presenilin-stabilization factor
• PSF

Background

APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: APH1A
• Entrez:
  • 51107(Human)
• Uniprot:
  • NP_001071096.1(Human)