APH1A Antibody

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Western Blot: APH1a Antibody [NB100-61660] - Analysis of APH1a antibody using this antibody at 0.01 ug/ml in Human Brain (Cerebral Cortex) lysate (35ug protein in RIPA buffer).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

APH1A Antibody Summary

Immunogen
Peptide with sequence C-HVTDRSDARLQYG corresponding to internal region according to NP_001071096.1, NP_057106.2.
Epitope
HVTDRSDARLQYG
Specificity
This antibody is expected to recognize isoform 1 (NP_001071096.1) and isoform 2 (NP_057106.2).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
APH1A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.05 - 0.1 ug/ml
  • Peptide ELISA Detection limit 1:128000
Application Notes
WB: Approx. 26 kDa band observed in human brain (cerebral cortex) lysates (calculated MW of 26.8 kDa band according to NP_057106.2).
Publications
Read Publication using NB100-61660.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Porcine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for APH1A Antibody

  • 6530402N02Rik
  • anterior pharynx defective 1 homolog A (C. elegans)
  • APH-1
  • APH1A
  • APH-1A
  • aph-1alpha
  • CGI-78
  • gamma-secretase subunit APH-1A
  • Presenilin-stabilization factor
  • PSF

Background

APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for APH1A Antibody (NB100-61660)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol APH1A
Entrez
Uniprot