Angiostatin Antibody (79735) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 79735
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Angiostatin Antibody (79735) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human Angiostatin Kringle 1-3
  Val98-Ser358 (Cys88Ser, Cys316Ser)
  Accession # P00747
• Specificity: Detects human Angiostatin Kringle 1-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody also detects plasminogen but does not cross-react with recombinant mouse Angiostatin.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Angiostatin Antibody (79735) [Alexa Fluor® 647]

• Angiostatin
• HAE4

Background

Plasminogen is the precursor of plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion. Synthesized in the kidney, plasminogen is found in plasma and many extracellular fluids. Activated by u- or t-plasminogen activator, the single-chain plasminogen is converted to plasmin that consists of a disulfide bond-linked heavy chain A and light chain B. Heavy chain A contains 5 kringle domains and light chain B corresponds to the serine protease domain. A fragment consisting of the first 4 kringle domains has been named angiostatin, a novel angiogenesis inhibitor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.