alpha-Synuclein Antibody (1060506) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clone: 1060506
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

alpha-Synuclein Antibody (1060506) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived human alpha-Synuclein
  Met1-Ala140
  Accession # P37840
• Specificity: Detects human alpha -Synuclein in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for alpha-Synuclein Antibody (1060506) [Alexa Fluor® 350]

• alpha-Synuclein
• I+/--synuclein
• MGC110988
• NACP
• non A-beta component of AD amyloid
• Non-A beta component of AD amyloid
• Non-A4 component of amyloid precursor
• PARK1
• PARK4
• PD1
• SNCA
• synuclein alpha-140
• synuclein, alpha (non A4 component of amyloid precursor)
• Synuclein-alpha
• truncated alpha synuclein

Background

alpha -Synuclein is member of a family of small soluble proteins that include also beta -, and gamma -Synuclein. It is predominantly expressed in neurons of the central nervous system in the presynaptic region of nerve terminals, where it cycles between a free, partially unfolded and a helical, membrane-bound form. alpha -Synuclein can self-aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates. The fibrils and amyloidal forms of alpha -Synuclein are major components of Lewy bodies and Lewy neurites and have been linked to the pathogenesis of Parkinson’s Disease, Parkinson’s Disease Dementia, and dementia with Lewy bodies. alpha -Synuclein aggregates can be also found associated with amyloid plaques in Alzheirmer’s Disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for alpha-Synuclein Antibody (FAB11376U). (Showing 1 - 1 of 1 FAQ).

1. I'm looking for an alpha-Synuclein antibody with an epitope located in the first half (N-terminus) of the protein - preferably a monoclonal antibody. Can you help me with that?
   • Please take a look at NB110-57475. It has been validated for human, rat and mouse and the applications ICC and WB and the epitope it detects is in the N terminal.