Reactivity | HuSpecies Glossary |
Applications | Flow, CyTOF-ready |
Clone | 491613 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Unconjugated |
Immunogen | NS0 mouse myeloma cell line transfected with human alpha ‑2B Adrenergic R/ADRA2B Accession # P18089 |
Specificity | Detects human alpha ‑2B Adrenergic R/ADRA2B in direct ELISAs. |
Source | N/A |
Isotype | IgG1 |
Clonality | Monoclonal |
Host | Mouse |
Purity Statement | Protein A or G purified from ascites |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
Secondary Antibodies |
Isotype Controls |
Diseases for alpha-2B Adrenergic R/ADRA2B Antibody (MAB10324)Discover more about diseases related to alpha-2B Adrenergic R/ADRA2B Antibody (MAB10324).
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PTMs for alpha-2B Adrenergic R/ADRA2B Antibody (MAB10324)Learn more about PTMs related to alpha-2B Adrenergic R/ADRA2B Antibody (MAB10324).
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