alpha-2B Adrenergic R/ADRA2B Antibody (491613) [Unconjugated]

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HEK293 human embryonic kidney cell line transfected with either (A) human ADRA2B or (B) irrelevant protein and eGFP was stained with Mouse Anti-Human ADRA2B Monoclonal Antibody (Catalog # MAB10324) followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
491613
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Catalog# & Formulation Size Price

alpha-2B Adrenergic R/ADRA2B Antibody (491613) [Unconjugated] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human alpha ‑2B Adrenergic R/ADRA2B
Accession # P18089
Specificity
Detects human alpha ‑2B Adrenergic R/ADRA2B in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25 ug/10^6 cells
  • CyTOF-ready

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for alpha-2B Adrenergic R/ADRA2B Antibody (491613) [Unconjugated]

  • a-2B AdrenergicR
  • ADRA2B adrenergic, alpha-2B-, receptor
  • ADRA2B
  • ADRA2L1
  • ADRA2L1adrenergic receptor alpha 2B
  • ADRA2RL1
  • ADRARL1
  • adrenergic, alpha-2B-, receptor
  • Alpha-2 adrenergic receptor subtype C2
  • alpha-2-adrenergic receptor-like 1
  • alpha-2B Adrenergic R
  • alpha-2B adrenergic receptor
  • alpha2B AdrenergicR
  • Alpha-2B adrenoceptor
  • Alpha-2B adrenoreceptor
  • alpha-2B-adrenergic receptor
  • ALPHA2BAR
  • alpha-2BAR
  • G-protein coupled receptor

Background

Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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