Aldo-keto Reductase 1C4/AKR1C4 Antibody

Western Blot: Aldo-keto Reductase 1C4/AKR1C4 Antibody [H00001109-D01P] - Analysis of AKR1C4 expression in human liver.

Western Blot: Aldo-keto Reductase 1C4/AKR1C4 Antibody [H00001109-D01P] - Analysis of AKR1C4 expression in transfected 293T cell line by AKR1C4 polyclonal antibody.Lane 1: AKR1C4 transfected lysate(37.20 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

Aldo-keto Reductase 1C4/AKR1C4 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: AKR1C4 (AAH20744.1, 1 a.a. - 323 a.a.) full-length human protein. MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYPFSDEY
• Specificity: AKR1C4 - aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4),
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AKR1C4
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Aldo-keto Reductase 1C4/AKR1C4 Antibody

• 3-alpha-HSD
• AKR1C4
• Aldo-keto Reductase 1C4
• aldo-keto reductase family 1, member C4
• AldoketoReductase 1C4
• C11
• CDR
• CHDR
• DD4
• DD-4
• HAKRA

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AKR1C4
• Entrez:
  • 1109(Human)
• Uniprot:
  • P17516(Human)