Aldo-keto Reductase 1C4/AKR1C4 Products

Description

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Bioinformatics

Entrez	1109 Human
Uniprot	P17516 Human
Product By Gene ID	1109
Alternate Names	3-alpha-HSD AKR1C4 Aldo-keto Reductase 1C4 aldo-keto reductase family 1, member C4 AldoketoReductase 1C4 C11 CDR CHDR DD4 DD-4 HAKRA

Research Areas for Aldo-keto Reductase 1C4/AKR1C4

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Lipid and Metabolism