ALDH2 Antibody

Western Blot: ALDH2 Antibody [NBP1-52051] - Staining of Mouse Liver lysate (35 ug protein in RIPA buffer). Antibody at 0.03 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu, Mu, Rt, Po, Bv, Ca
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

ALDH2 Antibody Summary

• Description: Novus Biologicals Goat ALDH2 Antibody (NBP1-52051) is a polyclonal antibody validated for use in WB and ELISA. Anti-ALDH2 Antibody: Cited in 2 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-DETQFKKILGYIN corresponding to internal region according to NP_000681.2.
• Epitope: C-DETQFKKILGYIN
• Predicted Species: Porcine (100%), Bovine (100%), Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ALDH2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
  • Western Blot 0.03 - 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ALDH2 Antibody

• acetaldehyde dehydrogenase 2
• aldehyde dehydrogenase 2 family (mitochondrial)
• aldehyde dehydrogenase, mitochondrial
• ALDH class 2
• ALDH2
• ALDH-E2
• ALDHI
• ALDM
• EC 1.2.1
• EC 1.2.1.3
• liver mitochondrial ALDH
• MGC1806
• nucleus-encoded mitochondrial aldehyde dehydrogenase 2

Background

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ALDH2 Antibody (NBP1-52051)(2)

Publications using NBP1-52051

• Munoz, D;Rivera-Meza, M;Flores-Bastias, O;Quintanilla, ME;Karahanian, E; Fenofibrate: a PPAR alpha agonist- increases alcohol dehydrogenase levels in the liver: implications for its possible use as an ethanol-aversive drug Adicciones 2019-03-29 [PMID: 31018006] (WB, Rat)
• Kimura M, Sawayama T, Matsushita S et al. Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics. Alcohol Clin Exp Res 2009-05-01 [PMID: 19298328]

Bioinformatics

• Gene Symbol: ALDH2
• Entrez:
  • 217(Human)
• Uniprot:
  • NP_000681.2(Human)