ALDH2 Products

Description

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq]

Bioinformatics

Entrez	217 Human
Uniprot	AAH02967 Human NM_000690 Human NP_000681 Human NP_000681.2 Human P05091 Human
Product By Gene ID	217
Alternate Names	acetaldehyde dehydrogenase 2 aldehyde dehydrogenase 2 family (mitochondrial) aldehyde dehydrogenase, mitochondrial ALDH class 2 ALDH-E2 ALDHI ALDM EC 1.2.1 EC 1.2.1.3 liver mitochondrial ALDH MGC1806 nucleus-encoded mitochondrial aldehyde dehydrogenase 2