AICDA Antibody (359218) [DyLight 755]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clone: 359218
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 755

AICDA Antibody (359218) [DyLight 755] Summary

• Immunogen: E. coli-derived recombinant human AICDA
  Met1-Leu198
  Accession # Q9GZX7
• Specificity: Detects human AICDA in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: AICDA
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for AICDA Antibody (359218) [DyLight 755]

• activation-induced cytidine deaminase
• AICDA
• AID
• AIDCytidine aminohydrolase
• Arp2
• CDA2
• HIGM2
• HIGM2EC 3.5.4.5
• integrated into Burkitt's lymphoma cell line Ramos

Background

Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AICDA