ADAM23 Antibody

Immunohistochemistry-Paraffin: ADAM23 Antibody [NBP1-81250] - Staining of human rectum shows strong cytoplasmic positivity in glandular cells and in smooth muscle cells in the stroma.

Product Discontinued

ADAM23 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: LLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILD
• Predicted Species: Mouse (93%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADAM23
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
• Application Notes: HIER pH 6 retrieval is recommended.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (87%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ADAM23 Antibody

• a disintegrin and metalloproteinase domain 23
• ADAM metallopeptidase domain 23
• ADAM23
• disintegrin and metalloproteinase domain-containing protein 23
• MDC3
• MDC-3
• MDC3ADAM 23
• MDC-L
• Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

Background

ADAM23 is a non-catalytic metalloprotease-like protein. It is highly expressed in the brain, primarily in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole, and weakly expressed in the heart. 3 isoforms are produced by alternative splicing, alpha, beta and gamma. ADAM23 may play a role in cell-cell and cell-matrix interactions. May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ADAM23 Antibody (NBP1-81250)(1)

Publication using NBP1-81250

• E T Costa, G F Barnabe, M Li et al. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. Oncogene 2014-03-24 [PMID: 24662834] (WB, IF/IHC, Human)

Bioinformatics

• Gene Symbol: ADAM23
• Entrez:
  • 8745(Human)
• Uniprot:
  • O75077()