ADAM23 Antibody

Product Discontinued

ADAM23 Antibody Summary

• Immunogen: Peptide with sequence NGKPQYSKGGEHC corresponding to internal region according to NP_003803.1.
• Epitope: NGKPQYSKGGEHC
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ADAM23
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
• Application Notes: WB: Preliminary experiments gave an approx. 70 kDa band in human brain (cerebellum and frontal cortex) lysates after 0.7 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe. The precursor of this glycoprotein has a calculated size of 91.9 kDa band according to NP_003803.1. The 70 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for ADAM23 Antibody

• a disintegrin and metalloproteinase domain 23
• ADAM metallopeptidase domain 23
• ADAM23
• disintegrin and metalloproteinase domain-containing protein 23
• MDC3
• MDC-3
• MDC3ADAM 23
• MDC-L
• Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3

Background

ADAM23 is a non-catalytic metalloprotease-like protein. It is highly expressed in the brain, primarily in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole, and weakly expressed in the heart. 3 isoforms are produced by alternative splicing, alpha, beta and gamma. ADAM23 may play a role in cell-cell and cell-matrix interactions. May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ADAM23 Antibody (NBP1-52129)(1)

Publication using NBP1-52129

• Takada H, Imoto I, Tsuda H et al. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. Oncogene 2005-12-01 [PMID: 16103878]

Bioinformatics

• Gene Symbol: ADAM23
• Entrez:
  • 8745(Human)
• Uniprot:
  • NP_003803.1(Human)