ACP6 Antibody

Images

 
Western blot shows lysates of human prostate tissue and human testis tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human ACP6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7766) followed by ...read more
ACP6 was detected in immersion fixed paraffin-embedded sections of human ovarian cancer tissue using Sheep Anti-Human ACP6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7766) at 5 µg/mL overnight at 4 °C. ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

ACP6 Antibody Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ACP6
Glu33-Glu428
Accession # BAA91310
Specificity
Detects human ACP6 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
ACP6
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ACP6 Antibody

  • acid phosphatase 6, lysophosphatidicPACPL1
  • Acid phosphatase-like protein 1
  • ACP6
  • ACPL1
  • ACPL1acid phosphatase like 1
  • EC 3.1.3.2
  • LPAP
  • LPAPlysophosphatidic acid phosphatase type 6
  • PACPL1

Background

ACP6 (Acid Phosphatase 6, lysophosphatidic; also lysophosphatidic acid phosphatase type 6, LPAP and ACPL1) is a 44-47 kDa monomeric member of the histidine acid phosphatase family of proteins. It is widely expressed, being found in almost all tissues, particularly in mitochondria-rich cells. ACP6 has been described as being both secreted and mitochondrial in location, and plays a critical role in the regulation of lysophosphatidic acid (LPA). LPA is the most structurally simple, biologically active phospholipid in nature (mono-[variable length] acyl-phosphoglycerol). It exists both inside and outside the cell, serving intracellularly as a modulator of lipid rafts, and extracellularly as a signaling molecule that promotes cell growth and fibroblast chemotaxis. ACP6 hydrolyzes LPA, generating monoacylglycerol and phosphate. This presumably eliminates its bioactivity. Human ACP6 precursor is 428 amino acids (aa) in length. It contains a putative signal sequence (aa 1-32) plus a 396 aa mature region (aa 33-428) that possesses one histidine phosphatase domain (aa 120-379). There is one isoform variant that contains an 11 aa substitution for aa 261-428. Mature human ACP6 shares 76% aa sequence identity with mouse ACP6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Bioinformatics

Gene Symbol ACP6
Uniprot