ACBP Antibody

Western Blot: ACBP Antibody [H00001622-D01P] - Analysis of DBI expression in transfected 293T cell line by DBI polyclonal antibody.Lane 1: DBI transfected lysate(11.80 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

ACBP Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: DBI (NP_065438.1, 1 a.a. - 104 a.a.) full-length human protein. MWGDLWLLPPASANPGTGTEAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DBI
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: It has been used for WB.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ACBP Antibody

• ACBP
• acyl-Coenzyme A binding domain containing 1
• acyl-Coenzyme A bindingprotein)
• CCK-RP
• cholecystokinin-releasing peptide, trypsin-sensitive
• DBI
• diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
• Diazepam-binding inhibitor
• Endozepine
• EP
• GABA receptor modulator
• MGC70414

Background

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DBI
• Uniprot:
  • NP_065438.1(Human)