SR-BI Products

Antibodies
SR-BI Antibody
SR-BI Antibody
NB400-113
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, B/N
Host: Rabbit Polyclonal
Lysates
SR-BI Overexpression Lysate
SR-BI Overexpression Lysate
NBL1-15720
Species: Hu
Applications: WB
Proteins
SR-BI Blocking Peptide
SR-BI Blocking Peptide
NB400-101PEP
Species: Mu
SR-BI Blocking Peptide
SR-BI Blocking Peptide
NB400-131PEP
Species: Mu
Recombinant Mouse SR-BI Fc Ch ...
Recombinant Mouse SR-BI Fc Chimera...
9644-SR
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

SR-BI (scavenger receptor class B member 1, SCARB1) belongs to the CD36 family and acts as a cell surface lipoprotein receptor for a variety of ligands including high density lipoprotein (HDL), phospholipids, phosphatidylserine, and lipoproteins such as lipopolysaccharide (LPS). SR-BI mediates selective uptake of HDL cholesteryl (HDL-C) ester in the liver, steroidogenic tissues, and adipose tissue and facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins. SR-BI plays a role in antigen capture and cross-presentation from bacteria, parasites, and viruses such as Hepatitis C. In endothelial cells and macrophages, SR-BI is involved in anti-inflammatory and pro-survival signaling, providing protection against atherosclerosis and clearing apoptotic cells (efferocytosis) (1, 2).

At least 5 different human splice variants have been identified with theoretical molecular weights ranging from 60.9 kDa for the canonical sequence to 45 kDa for an N-terminally truncated variant (SR-BII) (3). The extracellular domain of human SR-BI (CLA-1) shares 80%, 80%, 89%, 86% and 84% aa sequence identity with mouse, rat, porcine, rabbit, and bovine SR-BI, respectively. SR-BI is highly glycosylated and removal of N-linked glycosylation reduces lipid transport.

References

1. Linton MF, Tao H, Linton EF, Yancey PG. (2017) SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. Trends Endocrinol Metab. 28(6):461-472. PMID: 28259375

2. Hoekstra M, Sorci-Thomas M. (2017) Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor. Curr Opin Lipidol. 28(3):255-260. PMID: 28301373

3. Shen WJ, Asthana S, Kraemer FB, Azhar S. (2018) Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Mouse
Rat
Product By Gene ID 949
Alternate Names
  • SR-B1
  • MGC138242
  • SCARB1
  • CD36 antigen
  • Collagen type I receptor, thrombospondin receptor-like 1
  • scavenger receptor class B type III
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
  • CD36L1scavenger receptor class B type 1
  • SRB1 scavenger receptor class B member 1
  • SRBI
  • CLA-1 HDLQTL6
  • CLA1 CD36 antigen-like 1
  • CD36 and LIMPII analogous 1
  • scavenger receptor class B, member 1

Research Areas for SR-BI

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Cholesterol Metabolism
Lipid and Metabolism
Signal Transduction

Bioinformatics Tool for SR-BI

Discover related pathways, diseases and genes to SR-BI. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related SR-BI Blog Posts

Check out the latest blog posts on SR-BI.
ABCA1 (ATP-binding cassette transporter A1)
The ABCA1 molecule is a primary gatekeeper for regulating the intracellular transport of cholesterol. It belongs to a larger related multifamily of cAMP-dependent anion transporter cell membrane molecules. These key proteins are responsible for tr...    Read more.
ABCA1 - The Caretaker for Cholesterol Transportation
The ATP-binding cassette transporter A1 (ABCA1) protein is a key gatekeeper for regulating intracellular cholesterol transport. It is one member of a large family of genes comprised of cAMP-dependent anion transporter cell membrane proteins. These imp...    Read more.
Scavenger's Helper - SR-BI (scavenger receptor class B member 1, SCARB1)
SR-B1 belongs to the CD36 scavenger receptor family and serves as a receptor for several ligands including phospholipids, cholesterol ester, lipoproteins, phosphatidylserine, and caveolae localized HDL. It is expressed in endothelial cells, macrophage...    Read more.
Read more SR-BI related blogs.