Description
SR-BI (scavenger receptor class B member 1, SCARB1) belongs to the
CD36 family and acts as a cell surface lipoprotein receptor for a variety of ligands including
high density lipoprotein (HDL), phospholipids, phosphatidylserine, and lipoproteins such as lipopolysaccharide (LPS). SR-BI mediates selective uptake of HDL cholesteryl (HDL-C) ester in the liver, steroidogenic tissues, and adipose tissue and facilitates the flux of free and esterified cholesterol between the cell surface and
apoB-containing lipoproteins and modified lipoproteins. SR-BI plays a role in antigen capture and cross-presentation from
bacteria, parasites, and
viruses such as
Hepatitis C. In
endothelial cells and macrophages, SR-BI is involved in anti-inflammatory and pro-survival signaling, providing protection against atherosclerosis and clearing
apoptotic cells (efferocytosis) (1, 2).
At least 5 different human splice variants have been identified with theoretical molecular weights ranging from 60.9 kDa for the canonical sequence to 45 kDa for an N-terminally truncated variant (
SR-BII) (3). The extracellular domain of human SR-BI (CLA-1) shares 80%, 80%, 89%, 86% and 84% aa sequence identity with mouse, rat, porcine, rabbit, and bovine SR-BI, respectively. SR-BI is highly glycosylated and removal of N-linked glycosylation reduces lipid transport.
References
1. Linton MF, Tao H, Linton EF, Yancey PG. (2017) SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis. Trends Endocrinol Metab. 28(6):461-472. PMID: 28259375
2. Hoekstra M, Sorci-Thomas M. (2017) Rediscovering scavenger receptor type BI: surprising new roles for the HDL receptor. Curr Opin Lipidol. 28(3):255-260. PMID: 28301373
3. Shen WJ, Asthana S, Kraemer FB, Azhar S. (2018) Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function.
Bioinformatics
| Product By Gene ID |
949 |
| Alternate Names |
- CD36 and LIMPII analogous 1
- CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
- CD36 antigen
- CD36L1
- CD36L1scavenger receptor class B type 1
- CLA1 CD36 antigen-like 1
- CLA-1 HDLQTL6
- CLA1
- Collagen type I receptor, thrombospondin receptor-like 1
- HDLQTL6
- MGC138242
- SCARB1
- scavenger receptor class B type III
- scavenger receptor class B, member 1
- SRB1 scavenger receptor class B member 1
- SR-B1
- SRBI
- SR-BI
|
