LIMPII/SR-B2 Products

Description

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different. SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes. Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor. In addition, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells. The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Bioinformatics

Entrez	117106 Rat 12492 Mouse 950 Human
Uniprot	AAH21892 Human NP_005497 Human NP_005497.1 Human O35114 Mouse Q14108 Human
Product By Gene ID	950
Alternate Names	AMRF CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2(lysosomal integral membrane protein II) CD36 antigen CD36L2LIMP II HLGP85 LGP85 LIMP-2,85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2 LIMPIICD36 antigen-like 2 lysosome membrane protein 2 Lysosome membrane protein II Scavenger receptor class B member 2,85 kDa lysosomal membrane sialoglycoprotein scavenger receptor class B, member 2 SR-BII

Research Areas for LIMPII/SR-B2

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Cholesterol Metabolism
GPCR
Lipid and Metabolism
Lysosome Markers
Neuronal Cell Markers
Neuroscience
Neurotransmission
Signal Transduction