PGC1 alpha Products

Antibodies
PGC1 alpha Antibody
PGC1 alpha Antibody
Species: Hu, Mu, Rt, Po, Gt, Ha, Sq, Ca, Eq, Pm
Applications: WB, ChIP, Flow, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, IP, KO
Host: Rabbit Polyclonal
PGC1 alpha Antibody
PGC1 alpha Antibody
NB100-60955
Species: Hu, Mu, Rt, Po, Bv, Ca
Applications: WB, Flow, ICC/IF, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
PGC1 alpha [p Ser571] Antibod ...
PGC1 alpha [p Ser571] Antibody [Un...
AF6650
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
Proteins
Recombinant Human PGC1 alpha ...
Recombinant Human PGC1 alpha Protein
H00010891-Q01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1alpha), PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha (theoretical molecular weight 91 kDa) belongs to a family of transcription coactivators which includes two other proteins; PGC-1beta and PGC-1-related coactivators. PGC1 alpha interacts with various transcription factors (e.g., FOXO1, PPAR-(alpha, delta and gamma), LXR and FXR), promoting the transactivation of their specific target genes (1). As a transcription coactivator, PGC1 alpha is found in the nucleus where it interacts with transcriptional activators and chromatin modifiers such as p300/CBP and SRC-1 to induce targeted gene expression (1, 2). Transcription factors which interact with PGC1 alpha are involved in several functions related to cellular energy homeostasis including mitochondrial biogenesis, glucose and fatty acid metabolism, and skeletal muscle remodeling. Upstream regulators of PGC1 alpha activity include proteins that play a central role as energy sensors including SIRT1 and AMPK which, through different mechanisms, induce PGC1 alpha activity (3).

PGC1 alpha is highly expressed in skeletal muscle, cardiac muscle, and brown adipose tissue, all tissues with high oxidative capacity (1, 2). PGC1 alpha is also induced by energy taxing physiological states, for example increased physical activity, reduced body temperature, and reduced food intake (3). Because of its role in pathways controlling cellular energy expenditure, PGC1 alpha dysfunction has been associated with pathophysiological conditions such as type 2 diabetes and the metabolic syndrome (3).

References

1.Liang, H., & Ward, W. F. (2006). PGC-1alpha: A key regulator of energy metabolism. American Journal of Physiology - Advances in Physiology Education. https://doi.org/10.1152/advan.00052.2006

2.Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O.,... Spiegelman, B. M. (2005). Transcriptional coactivator PGC-1alpha controls the energy state and contractile function of cardiac muscle. Cell Metabolism. https://doi.org/10.1016/j.cmet.2005.03.002

3.Canto, C., & Auwerx, J. (2009). PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Current Opinion in Lipidology. https://doi.org/10.1097/MOL.0b013e328328d0a4

Bioinformatics

Uniprot Human
Human
Product By Gene ID 10891
Alternate Names
  • L-PGC-1alpha
  • PPARgamma coactivator 1alpha
  • peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext
  • peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a
  • peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT
  • PGC-1(alpha)
  • PGC1
  • PGC-1v
  • PPARGC1
  • PGC1A
  • PPARGC-1-alpha
  • PPAR gamma coactivator-1
  • PGC-1-alpha
  • PPAR gamma coactivator variant form
  • LEM6
  • peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  • Ligand effect modulator 6
  • ligand effect modulator-6
  • peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
  • PGC1APGC-1(alpha)
  • PGC1peroxisome proliferative activated receptor, gamma, coactivator 1
  • PPAR-gamma coactivator 1-alpha
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Research Areas for PGC1 alpha

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Chromatin Research
Diabetes Research
Lipid and Metabolism
mTOR Pathway
Neuroscience
Transcription Factors and Regulators

Bioinformatics Tool for PGC1 alpha

Discover related pathways, diseases and genes to PGC1 alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.