Hu, Mu, Rt, Ha, Sq, Ca, Eq, PmApplications:
WB, ChIP, Flow, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, IPHost:
Applications: WB, ELISA, PA, AP
Applications: RNAi, RNAi SP
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) is a transcriptional coactivator responsible for regulating genes involved in energy metabolism. PGC1a is a master integrator of external signals. The protein interacts with multiple transcription factors and acts as a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis. Some PGC1a activators include reactive oxygen species and reactive nitrogen species, as well as CREB, Akt and SIRT1 proteins. Additional functions of PGC1 alpha include regulating muscle fiber type determination, blood pressure, cellular cholesterol homoeostasis, and obesity development.
Recently PGC-1alpha has been suggested as a potential therapy for Parkinson's Disease, as the protein is thought to protect mitochondrial metabolism.
The PPARGC1A gene is also known as human accelerated region 20, and is thought to have played a key role in differentiating humans and apes.
|Product By Gene ID
- PPAR gamma coactivator-1
- PPAR gamma coactivator variant form
- peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Ligand effect modulator 6
- ligand effect modulator-6
- peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
- PGC1peroxisome proliferative activated receptor, gamma, coactivator 1
- PPAR-gamma coactivator 1-alpha
- peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Bioinformatics Tool for PGC1 alpha
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