PPAR alpha/NR1C1 Products

Antibodies
PPAR alpha/NR1C1 Antibody
PPAR alpha/NR1C1 Antibody
Species: Hu, Mu, Rt, Bv, Ca, Ha
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, ChIP
Host: Rabbit Polyclonal
PPAR alpha/NR1C1 Antibody
PPAR alpha/NR1C1 Antibody
NBP1-03288
Species: Hu, Mu, Rt, Po, Bv, Ca, Ha
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Kits
PPAR alpha/NR1C1 Colorimetric ...
PPAR alpha/NR1C1 Colorimetric Assa...
KA1356
Applications: Func
Lysates
PPAR alpha/NR1C1 Overexpressi ...
PPAR alpha/NR1C1 Overexpression Ly...
H00005465-T01
Species: Hu
Applications: WB
PPAR alpha/NR1C1 Overexpressi ...
PPAR alpha/NR1C1 Overexpression Ly...
NBP2-11189
Applications: WB
PPAR alpha/NR1C1 Overexpressi ...
PPAR alpha/NR1C1 Overexpression Ly...
NBP2-10726
Applications: WB
Proteins
Recombinant Human PPAR alpha/ ...
Recombinant Human PPAR alpha/NR1C1...
H00005465-P01
Species: Hu
Applications: WB, ELISA, PA
PPAR alpha/NR1C1 Recombinant ...
PPAR alpha/NR1C1 Recombinant Prote...
NBP2-57777PEP
Species: Hu
Applications: AC
PPAR alpha/NR1C1 Recombinant ...
PPAR alpha/NR1C1 Recombinant Prote...
NBP2-58507PEP
Species: Hu
Applications: AC
RNAi
PPAR alpha/NR1C1 RNAi
PPAR alpha/NR1C1 RNAi
H00005465-R01
Species: Hu
Applications: RNAi, RNAi SP
PPAR alpha/NR1C1 RNAi
PPAR alpha/NR1C1 RNAi
H00005465-R03
Species: Hu
Applications: RNAi, RNAi SP
PPAR alpha/NR1C1 RNAi
PPAR alpha/NR1C1 RNAi
H00005465-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase & cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. The corresponding gene for the PPAR alpha is NR1C1.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 5465
Alternate Names
  • PPARalpha
  • Nuclear receptor subfamily 1 group C member 1
  • alpha
  • hPPAR
  • PPARMGC2452
  • NR1C1MGC2237
  • PPAR-alpha
  • peroxisome proliferator-activated receptor alpha

Research Areas for PPAR alpha/NR1C1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Transcription Factors and Regulators

PTMs for PPAR alpha/NR1C1

Learn more about PTMs related to PPAR alpha/NR1C1.

Oxidation
Methylation
Reduction
Cleavage
Deacetylation

Bioinformatics Tool for PPAR alpha/NR1C1

Discover related pathways, diseases and genes to PPAR alpha/NR1C1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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