NLRP3/NALP3 Products

NLRP3/NALP3 Antibody
NLRP3/NALP3 Antibody
Species: Hu, Mu, Rt, RM
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IM
Host: Rabbit Polyclonal
NLRP3/NALP3 Overexpression Ly ...
NLRP3/NALP3 Overexpression Lysate
Species: Hu
Applications: WB
NLRP3/NALP3 Overexpression Ly ...
NLRP3/NALP3 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human NLRP3/NALP3 ...
Recombinant Human NLRP3/NALP3 Protein
Species: Hu
Applications: WB, ELISA, Func, PA, PAGE, AP
NLRP3/NALP3 Blocking Peptide
NLRP3/NALP3 Blocking Peptide
Species: Hu
Applications: AC
Recombinant Human NLRP3/NALP3 ...
Recombinant Human NLRP3/NALP3 Protein
Species: Hu
Applications: WB, ELISA, PA, AP


NLRP3/NALP3 (NLR family, pyrin domain containing 3), aka CIAS1 or Cryopyrin, belongs to a family of innate immune cytoplasmic receptors family containing a NACHT domain and a leucine rich repeats (LRRs) nucleotide-binding oligomerization doman (NOD)-like receptors. The NLR family's amino-terminal effector region is build out of either one of the three domains: a pyrin (PYD), a baculorvirus inhibitor of apoptosis protein repeat (BIR), or a caspase activation and recruitment (CARD). The NLR proteins hold a varieties of functionality within the innate immune responses such as pathogen sensing, proinflammatory cytokinese via NF-kappa-B and iF-1 through IRFs transcriptional activations, and the inflammasomes formation triggering inflammatory caspases. As a global sensor, NLRP3/NALP3 inflammasomes react and group together in response to a wide level of pathogen associated molecular patterns (PAMPs) and danger associated molecular patterns (DAMPs). NLRP3/NALP3 mutations can result in familial cold autoinflammatory syndrome, Muckle-Well syndrome, and neonatal onset multisystem inflammatory disease.


Uniprot Human
Product By Gene ID 114548
Alternate Names
  • Leucine-rich repeat-, and PYD-containing protein 3
  • Cold autoinflammatory syndrome 1
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3
  • PYRIN-containing APAF1-like protein 1
  • CLR1.1
  • Familial cold autoinflammatory syndrome
  • FCU
  • Muckle-Wells syndrome
  • NALP3
  • NLRP3
  • PYPAF1
  • Angiotensin/vasopressin receptor AII/AVP-like
  • Cold autoinflammatory syndrome 1 protein
  • Cryopyrin
  • Caterpiller protein 1.1
  • MWS
  • NACHT, LRR and PYD domains-containing protein 3
  • AVP
  • NACHT, LRR and PYD containing protein 3
  • AII
  • C1orf7
  • NLR family, pyrin domain containing 3

Research Areas for NLRP3/NALP3

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research

Bioinformatics Tool for NLRP3/NALP3

Discover related pathways, diseases and genes to NLRP3/NALP3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related NLRP3/NALP3 Blog Posts

Check out the latest blog posts on NLRP3/NALP3.
NLRP3/NALP3 - Sensing and responding to pathogen infection
The inflammasome is a multi protein complex that is an important component of the innate immune response. The inflammasome is able to sense and respond to pathogen infections by recognizing pathogen-associated molecular patterns and mediating the ...    Read more.
Read more NLRP3/NALP3 related blogs.