NLRP3/NALP3 Products

Antibodies
NLRP3/NALP3 Antibody
NLRP3/NALP3 Antibody
NBP2-12446
Species: Hu, Mu, Rt, RM
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IM, KD
Host: Rabbit Polyclonal
Lysates
NLRP3/NALP3 Overexpression Ly ...
NLRP3/NALP3 Overexpression Lysate
NBL1-13675
Species: Hu
Applications: WB
NLRP3/NALP3 Overexpression Ly ...
NLRP3/NALP3 Overexpression Lysate
NBP2-10634
Species: Hu
Applications: WB
Proteins
Recombinant Human NLRP3/NALP3 ...
Recombinant Human NLRP3/NALP3 GST ...
H00114548-P01
Species: Hu
Applications: WB, ELISA, Func, PA, PAGE, AP, Enzyme Activity, KA
NLRP3/NALP3 Antibody Blocking ...
NLRP3/NALP3 Antibody Blocking Peptide
NBP1-77080PEP
Species: Hu
Applications: AC
Recombinant Human NLRP3/NALP3 ...
Recombinant Human NLRP3/NALP3 GST ...
H00114548-Q01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

NACHT, LRR and PYD domains-containing protein 3 (NALP3), Nucleotide-Binding Oligomerization Domain, or Leucine Rich Repeat and Pyrin Domain Containing 3 (NLRP3) (human NLRP3-isoform 2 theoretical molecular weight 118kDa) acts as a cytosolic receptor for stress-signals initiated by a wide variety of pathogen-associated molecular patterns (PAMPS) and danger-associated molecular patterns (DAMPs) (1). NLRP3 belongs to the family of NOD-like receptors, a type of pattern-recognition receptor (PRR) which participates in innate immune responses. The exact mechanisms leading to NLRP3 activation are still not fully resolved. Some proposed mechanisms for NLRP3 inflammasome activation include induced ion channel flux as exemplified by potassium efflux, sodium influx and calcium signaling, generation of mitochondrial reactive oxygen species (ROS), and lysosomal destabilization (2). Activation of NLRP3 induces its association with the adaptor protein Apoptosis-associated Speck-like protein containing CARD (ASC) forming a complex that binds to Caspase-1 (1, 2). The inflammasome complex, comprised of NLRP3, ASC and Caspase 1, induces the processing of pro-IL-1beta and pro-IL-18 and release of the mature inflammatory cytokines IL-1betaand IL-18 and pyroptosis (1-3).

NLRP3 is expressed in a variety of cell types such as monocytes, dendritic cells, lymphocytes and epithelial cells (3). Abnormal NLRP3 activation may occur as the result of inherited mutations and is associated with diseases such as hereditary periodic fevers (HPFs) and familial cold autoinflammatory syndrome (FCAS). Additionally, abnormal NLRP3 activation is associated with a variety of diseases such as gout, obesity, atherosclerosis, Alzheimers, multiple sclerosis and type 2 diabetes (1, 3). NLRP3 inflammasome is regulated by several post-translational modifications (e.g., ubiquitination, phosphorylation and sumoylation) as well as by various interacting proteins (e.g., JNK1, FBXO3, TXNIP, MARK4 and PKD) (4).

References

1. Abderrazak, A., Syrovets, T., Couchie, D., El Hadri, K., Friguet, B., Simmet, T., & Rouis, M. (2015). NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biology. https://doi.org/10.1016/j.redox.2015.01.008

2. Yang, Y., Wang, H., Kouadir, M., Song, H., & Shi, F. (2019). Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death and Disease. https://doi.org/10.1038/s41419-019-1413-8

3. Zahid, A., Li, B., Kombe, A. J. K., Jin, T., & Tao, J. (2019). Pharmacological inhibitors of the nlrp3 inflammasome. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2019.02538

4. Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019). The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20133328

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 114548
Alternate Names
  • AII/AVP
  • Leucine-rich repeat-, and PYD-containing protein 3
  • Cold autoinflammatory syndrome 1
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3
  • PYRIN-containing APAF1-like protein 1
  • CLR1.1
  • Familial cold autoinflammatory syndrome
  • FCU
  • Muckle-Wells syndrome
  • NALP3
  • NLRP3
  • PYPAF1
  • Angiotensin/vasopressin receptor AII/AVP-like
  • Cold autoinflammatory syndrome 1 protein
  • Cryopyrin
  • Caterpiller protein 1.1
  • MWS
  • NACHT, LRR and PYD domains-containing protein 3
  • AVP
  • NACHT, LRR and PYD containing protein 3
  • AII
  • C1orf7
  • NLR family, pyrin domain containing 3

Research Areas for NLRP3/NALP3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cytokine Research

Bioinformatics Tool for NLRP3/NALP3

Discover related pathways, diseases and genes to NLRP3/NALP3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related NLRP3/NALP3 Blog Posts

Check out the latest blog posts on NLRP3/NALP3.
NLRP3/NALP3 - Sensing and responding to pathogen infection
The inflammasome is a multi protein complex that is an important component of the innate immune response. The inflammasome is able to sense and respond to pathogen infections by recognizing pathogen-associated molecular patterns and mediating the ...    Read more.
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