MARK4 Products

Description

MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells. Northern blot analysis reveals ubiquitous expression of a 3.6kb transcript, with highest expression in testis. Immunofluorescence microscopy demonstrates homogeneous cytoplasmic expression. Colony forming assays show that MARK4 antisense reduces the growth of SNU475 cells. It has been suggested that MARK4 provides a growth advantage to cells.

Bioinformatics

Product By Gene ID	57787
Alternate Names	EC 2.7.11 EC 2.7.11.1 FLJ12177 FLJ90097 KIAA1860MARK4L MAP/microtubule affinity-regulating kinase 4 MAP/microtubule affinity-regulating kinase like 1 MAP/microtubule affinity-regulating kinase-like 1 MARK4 serine/threonine protein kinase MARKL1L MARKL1MARK4S Nbla00650

Research Areas for MARK4

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Apoptosis