ASC/TMS1 Products

Antibodies
ASC/TMS1 Antibody (1C3D7)
ASC/TMS1 Antibody (1C3D7)
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
ASC/TMS1 Overexpression Lysat ...
ASC/TMS1 Overexpression Lysate
NBL1-15017
Species: Hu
Applications: WB
ASC/TMS1 Overexpression Lysat ...
ASC/TMS1 Overexpression Lysate
NBL1-15016
Species: Hu
Applications: WB
Proteins
Recombinant Human ASC/TMS1 GS ...
Recombinant Human ASC/TMS1 GST (N-...
H00029108-P01
Species: Hu
Applications: WB, ELISA, Func, PA, AP
ASC/TMS1 Antibody Blocking Pe ...
ASC/TMS1 Antibody Blocking Peptide
NBP1-77297PEP
Species: Hu
Applications: AC
ASC/TMS1 Recombinant Protein ...
ASC/TMS1 Recombinant Protein Antigen
NBP2-48925PEP
Species: Hu
Applications: AC

Description

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 29108
Alternate Names
  • apoptosis-associated speck-like protein containing a CARD
  • ASC
  • CARD5
  • PYCARD
  • TMS
  • TMS1
  • Target of methylation-induced silencing 1
  • hASC
  • Caspase recruitment domain-containing protein 5
  • caspase recruitment domain protein 5
  • TMS-1
  • PYD and CARD domain-containing protein

Research Areas for ASC/TMS1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology

PTMs for ASC/TMS1

Learn more about PTMs related to ASC/TMS1.

Methylation
Cleavage
Demethylation
Phosphorylation
Acetylation
Deacetylation
Reduction
Acylation

Bioinformatics Tool for ASC/TMS1

Discover related pathways, diseases and genes to ASC/TMS1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ASC/TMS1 Blog Posts

Check out the latest blog posts on ASC/TMS1.
The inflammasome: an inflammation-initiating machine, Novus Biologicals
By Stephanie Melchor The inflammasome is a large, multimeric protein complex found primarily in innate immune cells, which are white blood cells that can attack a wide range of pathogenic threats. Three main elements...    Read more.
Immunity’s flipside: Microglia promote Alzheimer’s pathology during inflammation
By Jamshed Arslan Pharm.D. Microglia are brain's macrophages. In Alzheimer's disease (AD), microglia clear up protein aggregates called amyloid beta plaques. The connection between immune activation and AD is unclea...    Read more.
CARD & NFKB Antibodies for Apoptosis Research
Apoptosis is one of the main types of programmed cell death which involves a cascade of biochemical events leading to specific cell morphology characteristics and ultimately death of cells.Caspases play crucial roles in modulating cellular signaling...    Read more.
Read more ASC/TMS1 related blogs.