ASC/TMS1 Products

Antibodies
ASC/TMS1 Antibody (SN07-10)
ASC/TMS1 Antibody (SN07-10)
NBP2-67697
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Rabbit Monoclonal
Lysates
ASC/TMS1 Overexpression Lysat ...
ASC/TMS1 Overexpression Lysate
NBL1-15016
Species: Hu
Applications: WB
ASC/TMS1 Overexpression Lysat ...
ASC/TMS1 Overexpression Lysate
NBL1-15017
Species: Hu
Applications: WB
Proteins
Recombinant Human ASC/TMS1 GS ...
Recombinant Human ASC/TMS1 GST (N-...
H00029108-P01
Species: Hu
Applications: WB, ELISA, Func, PA, AP
ASC/TMS1 Antibody Blocking Pe ...
ASC/TMS1 Antibody Blocking Peptide
NBP1-77297PEP
Species: Hu
Applications: AC
ASC/TMS1 Recombinant Protein ...
ASC/TMS1 Recombinant Protein Antigen
NBP2-48925PEP
Species: Hu
Applications: AC

Description

ASC (apoptosis-associated speck-like protein containing a CARD), also known as TMS1 (target of methylation-induced silencing), was first identified in 1999 as a protein that forms aggregates, or specks, during retinoic acid-induced apoptosis in a human leukemia cell line (1). Furthermore, it was discovered to have a role as a tumor suppressor as methylation silences ASC/TMS1 expression in many tumors (2-5). ASC/TMS1 is synthesized as a 195-amino acid (aa) protein with a theoretical weight of 22 kDa. Structurally the protein contains a N-terminal PYD (pyrin domain) and C-terminal CARD (caspase-recruitment domain) (1-4). Historically, CARD and PYD-containing proteins are known to have crucial functions in regulating apoptosis and immune response pathways (2-5). Furthermore, mutations in many CARD and PYD-containing proteins have been linked to various cancers and inflammatory diseases (2-5). Given its immune response role, it is not surprising that ASC/TMS1 is typically highly expressed in immune cells, specifically in neutrophils and cells of the macrophage/monocyte lineage (5). Additionally, it is expressed in many normal epithelial cell types (4,5).

In regard to immune and inflammatory response, ASC/TMS1 is involved in inflammasome function (3-4). The inflammasome is a multiprotein complex that responds to cellular stress or pathogens and activates inflammatory responses. Specifically, ASC/TMS1 helps assemble the NLRP3 inflammasome complex which then activates caspase-1, followed by stimulation of proinflammatory cytokines including IL-1b and IL-18 (3-4). In terms of the role in regulating apoptosis, multiple studies have revealed that the ASC/TMS1 gene is hypermethylated in many cancers including breast, lung, glioblastomas, and melanomas (2-5). The increased methylation results in decreased gene expression, or silencing, allowing those cancer cells to escape apoptosis (2-5).

References

1. Masumoto, J., Taniguchi, S., Ayukawa, K., Sarvotham, H., Kishino, T., Niikawa, N., Hidaka, E., Katsuyama, T., Higuchi, T., & Sagara, J. (1999). ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. The Journal of biological chemistry, 274(48), 33835-33838. https://doi.org/10.1074/jbc.274.48.33835

2. McConnell, B. B., & Vertino, P. M. (2004). TMS1/ASC: the cancer connection. Apoptosis: an international journal on programmed cell death. https://doi.org/10.1023/B:APPT.0000012117.32430.0c

3. Salminen, A., Kauppinen, A., Hiltunen, M., & Kaarniranta, K. (2014). Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. Cellular and molecular life sciences : CMLS. https://doi.org/10.1007/s00018-013-1524-9

4. Protti, M. P., & De Monte, L. (2020). Dual Role of Inflammasome Adaptor ASC in Cancer. Frontiers in cell and developmental biology. https://doi.org/10.3389/fcell.2020.00040

5. Parsons, M. J., & Vertino, P. M. (2006). Dual role of TMS1/ASC in death receptor signaling. Oncogene. https://doi.org/10.1038/sj.onc.1209684

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 29108
Alternate Names
  • apoptosis-associated speck-like protein containing a CARD
  • ASC
  • CARD5
  • PYCARD
  • TMS
  • TMS1
  • Target of methylation-induced silencing 1
  • hASC
  • Caspase recruitment domain-containing protein 5
  • caspase recruitment domain protein 5
  • TMS-1
  • PYD and CARD domain-containing protein

Research Areas for ASC/TMS1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology

PTMs for ASC/TMS1

Learn more about PTMs related to ASC/TMS1.

Methylation
Cleavage
Demethylation
Phosphorylation
Acetylation
Deacetylation
Reduction
Acylation

Bioinformatics Tool for ASC/TMS1

Discover related pathways, diseases and genes to ASC/TMS1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related ASC/TMS1 Blog Posts

Check out the latest blog posts on ASC/TMS1.
Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release
By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.
The inflammasome: an inflammation-initiating machine, Novus Biologicals
By Stephanie Melchor The inflammasome is a large, multimeric protein complex found primarily in innate immune cells, which are white blood cells that can attack a wide range of pathogenic threats. Three main elements...    Read more.
Immunity’s flipside: Microglia promote Alzheimer’s pathology during inflammation
By Jamshed Arslan Pharm.D. Microglia are brain's macrophages. In Alzheimer's disease (AD), microglia clear up protein aggregates called amyloid beta plaques. The connection between immune activation and AD is unclea...    Read more.
CARD & NFKB Antibodies for Apoptosis Research
Apoptosis is one of the main types of programmed cell death which involves a cascade of biochemical events leading to specific cell morphology characteristics and ultimately death of cells.Caspases play crucial roles in modulating cellular signaling...    Read more.
Read more ASC/TMS1 related blogs.