Hu, Mu, RtApplications:
WB, Simple Western, ICC/IF, IHC, IHC-PHost:
ICC/IF, IHC, IHC-P, WB (-)Host:
WB, Flow, IHC, IHC-PHost:
WB, ELISA, Func, PA
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
|Product By Gene ID
- Target of methylation-induced silencing 1
- Caspase recruitment domain-containing protein 5
- caspase recruitment domain protein 5
- TMS1apoptosis-associated speck-like protein containing a CARD
- PYD and CARD domain-containing protein
- PYD and CARD domain containing
Research Areas for ASC/TMS1
Find related products by research area and learn more about each of the different research areas below.ApoptosisCancerCell Biology
Bioinformatics Tool for ASC/TMS1
Discover related pathways, diseases and genes to ASC/TMS1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related ASC/TMS1 Blog Posts
Check out the latest blog posts on ASC/TMS1.
Read more ASC/TMS1 related blogs.
|CARD & NFKB Antibodies for Apoptosis Research
Apoptosis is one of the main types of programmed cell death which involves a cascade of biochemical events leading to specific cell morphology characteristics and ultimately death of cells.Caspases play crucial roles in modulating cellular signaling... Read more.