beta-Actin Products

Antibodies
beta-Actin Antibody (AC-15)
beta-Actin Antibody (AC-15)
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, Fe, Fi, Gp, Ha, Le, Ma, Pm, Rb, Sh, Sq, Ze, Dr(-)
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, ChIP, KD, KO
Host: Mouse Monoclonal
Lysates
beta-Actin Overexpression Lys ...
beta-Actin Overexpression Lysate
NBP2-10939
Species: Hu
Applications: WB
Proteins
Recombinant Human beta-Actin ...
Recombinant Human beta-Actin GST (...
H00000060-P01
Species: Hu
Applications: WB, ELISA, PA, AP
beta-Actin Recombinant Protei ...
beta-Actin Recombinant Protein Ant...
NBP2-54690PEP
Species: Hu
Applications: AC

Description

Actin is a highly conserved protein involved in cell motility, structure, and integrity. Six functional actin isoforms exist and were named based on their electrophoretic mobility and distribution including alpha-cardiac muscle actin (aCAA), alpha-skeletal muscle actin (aSKA), alpha-smooth muscle actin (aSMA), beta-cytoplasmic actin (bCYA), gamma-cytoplasmic actin (gCYA) and gamma-smooth muscle actin (gSMA) (1). The cytoplasmic isoforms, beta-actin and gamma-actin, are nearly identical, differing by only 4 amino acids at the N-terminus with a theoretical molecular weight of 42 kDa (2). Beta-actin is ubiquitously expressed in eukaryotic cells and considered a housekeeping gene which is frequently used as a loading control for assays involving protein detection, such as Western blotting (3,4).

References

1. Vandekerckhove J, Weber K. 1978. At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide. J Mol Biol. 126(4):783-802. PMID: 745245

2. Gimona M, Vandekerckhove J, Goethals M, Herzog M, Lando Z, Small JV. (1994) Beta-actin specific monoclonal antibody. Cell Motil Cytoskeleton. 27(2):108-16. PMID: 8162619

3. Holden VI, Lenio S, Kuick R, Ramakrishnan SK, Shah YM, Bachman MA. (2014) Bacterial siderophores that evade or overwhelm Lipocalin 2 induce HIF-1a and pro-inflammatory cytokine secretion in cultured respiratory epithelial cells Infect Immun. 82(9):3826-36 PMID: 24980968

4. Tsai WL, Yeh PH, Tsai CY, Ting CT, Chiu YH, Tao MH, Li WC, Hung SC. (2016) Efficient Programming of Human Mesenchymal Stem Cell Derived Hepatocytes by Epigenetic Regulations. J. Gastroenterol. Hepatol. 32(1):261-269. PMID: 27218433

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Rabbit
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Mouse
Rat
Product By Gene ID 60
Alternate Names
  • I(2)-Actin
  • B-Actin
  • Beta Actin
  • BRWS1
  • ACTB
  • Beta-actin
  • PS1TP5-binding protein 1
  • beta cytoskeletal actin
  • actin, cytoplasmic 1
  • PS1TP5BP1
  • actin, beta

Research Areas for beta-Actin

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix
Loading Controls
Signal Transduction
Stem Cell Markers

PTMs for beta-Actin

Learn more about PTMs related to beta-Actin.

Methylation
Phosphorylation
Biotinylation
Acetylation
Oxidation

Bioinformatics Tool for beta-Actin

Discover related pathways, diseases and genes to beta-Actin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related beta-Actin Blog Posts

Check out the latest blog posts on beta-Actin.

    Read more.
The use of Beta Actin (AC-15) as a loading control across multiple species
Actin is a fundamental component of the cytoskeleton, where it has the ability to create and break down actin filament formation in response to various cell needs.  Actin has six highly conserved isoforms, however beta and gamma actin are the two...    Read more.
Tips on choosing an ideal loading control antibody for Western Blotting
Western blotting is one of the most commonly used antibody assay techniques in cell and molecular biology research since its development over three decades ago, and is considered the gold standard for protein detection and quantification. When p...    Read more.
Beta-Actin's Role in Neuronal Plasticity
Beta-Actin is a highly conserved protein involved in cell growth, cytoskeletal and extracellular support structures and cell migration. Because beta-Actin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading contro...    Read more.
ACTB - an abundant cytoskeletal component with applications for gene expression analysis
Actin is the widely studied and ubiquitous cytoskeletal protein capable of forming dynamic microfilament structures. These filaments are essential for diverse cellular functions including cell shape, migration, cytokinesis, and intracellular traffi...    Read more.
A New Standard in Antibody Testing - Simple Western Certified Antibodies
The Western blot is one of the most commonly used antibody assay techniques in cell and molecular biology research since its development over three decades ago, and is considered the gold standard for protein detection and quantification. The tradi...    Read more.
Read more beta-Actin related blogs.