alpha-Smooth Muscle Actin Products

Antibodies
alpha-Smooth Muscle Actin Ant ...
alpha-Smooth Muscle Actin Antibody
NB300-978
Species: Hu, Mu, Rt, Rb, Ca
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, PEP-ELISA, IHC-FrFl
Host: Goat Polyclonal
alpha-Smooth Muscle Actin Ant ...
alpha-Smooth Muscle Actin Antibody
Species: Hu, Mu, Rt, Ca, Ze, Po, Bv, Ch, Rb, RM
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, KD
Host: Rabbit Polyclonal
Antibody Pairs
alpha-Smooth Muscle Actin Ant ...
alpha-Smooth Muscle Actin Antibody...
H00000059-AP41
Species: Hu
Applications: S-ELISA
Host: Monoclonal
ELISA Kits
Mouse alpha-Smooth Muscle Act ...
Mouse alpha-Smooth Muscle Actin EL...
NBP2-66429
Species: Mu
Applications: ELISA
Human alpha-Smooth Muscle Act ...
Human alpha-Smooth Muscle Actin EL...
NBP2-66423
Species: Hu
Applications: ELISA
Rat alpha-Smooth Muscle Actin ...
Rat alpha-Smooth Muscle Actin ELIS...
NBP2-66430
Species: Rt
Applications: ELISA
Lysates
alpha-Smooth Muscle Actin Ove ...
alpha-Smooth Muscle Actin Overexpr...
NBP2-11075
Species: Hu
Applications: WB
alpha-Smooth Muscle Actin Ove ...
alpha-Smooth Muscle Actin Overexpr...
NBL1-07272
Species: Hu
Applications: WB
Proteins
Recombinant Human alpha-Smoot ...
Recombinant Human alpha-Smooth Mus...
H00000059-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Recombinant Human alpha-Smoot ...
Recombinant Human alpha-Smooth Mus...
NBP2-22670
Species: Hu
Applications: PAGE

Description

Actin proteins are highly conserved in eukaryotic cells and are involved in cell motility, structure and integrity. Actin and myosin are involved in a myriad of cellular processes including locomotion, secretion, cytoplasmic streaming, phagocytosis and cytokinesis. Actin filaments, along with microtubules, comprise a major component of the cytoskeleton and play essential roles in regulating cell shape and movement. Actin has been found to be expressed in at least six isoforms, each encoded by a separate gene and expressed in a developmentally regulated and tissue-specific manner. Alpha, beta and gamma actin isoforms have been identified. Alpha actins are a major constituent of the contractile apparatus, whereas beta and gamma actins are involved in the regulation of cell motility.

ACTA2 encodes alpha Smooth Muscle Actin and is also known as alpha-actin, alpha-actin-2, aortic smooth muscle or alpha smooth muscle actin (alpha-SMA, SMactin, alpha-SM-actin, ASMA). Alpha Smooth Muscle Actin is frequently used as a marker of smooth muscle differentiation and has a theoretical molecular weight of 42 kDa. Smooth muscle alpha actin is one of a few genes whose expression is predominantly expressed in vascular smooth muscle cells that is used to study myofibroblasts and fibrosis (1). Excessive accumulation of alpha smooth muscle actin-positive (ACTA2+) activated myofibroblasts is observed in Idiopathic pulmonary fibrosis (2). Expression of smooth muscle alpha actin is regulated by cell proliferation and is altered in pathological conditions including atherosclerosis and is common in metastatic cancers (1,3).

References

1. Chakraborty, R., Saddouk, F. Z., Carrao, A. C., Krause, D. S., Greif, D. M., & Martin, K. A. (2019). Promoters to Study Vascular Smooth Muscle. Arterioscler Thromb Vasc Biol, 39(4), 603-612. doi:10.1161/atvbaha.119.312449

2.El Agha, E., Moiseenko, A., Kheirollahi, V., De Langhe, S., Crnkovic, S., Kwapiszewska, G.,... Bellusci, S. (2017). Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. Cell Stem Cell, 20(2), 261-273.e263. doi:10.1016/j.stem.2016.10.004

3. Chen, Y. C., Gonzalez, M. E., Burman, B., Zhao, X., Anwar, T., Tran, M.,... Kleer, C. G. (2019). Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer. Cell Rep, 27(13), 3916-3926.e3915. doi:10.1016/j.celrep.2019.05.084

Bioinformatics

Product By Gene ID 59
Alternate Names
  • ACTSA
  • alpha SMA
  • a-sma
  • sma
  • smooth muscle actin
  • alpha-SMA
  • Cell growth-inhibiting gene 46 protein
  • growth-inhibiting gene 46
  • AAT6
  • actin, alpha 2, smooth muscle, aorta
  • actin, aortic smooth muscle
  • ACTVS
  • alpha 2 actin
  • alpha smooth muscle actin
  • Alpha-actin-2
  • alpha-actin-2

PTMs for alpha-Smooth Muscle Actin

Learn more about PTMs related to alpha-Smooth Muscle Actin.

Phosphorylation
Acetylation
Cleavage
Oxidation
Ubiquitination
Reduction
Dephosphorylation
Methylation
Geranylgeranylation
Prenylation

Bioinformatics Tool for alpha-Smooth Muscle Actin

Discover related pathways, diseases and genes to alpha-Smooth Muscle Actin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related alpha-Smooth Muscle Actin Blog Posts

Check out the latest blog posts on alpha-Smooth Muscle Actin.
Alpha-smooth muscle actin and the modulation of endothelial and epithelial cell biology
Actin is essential for a wide range of cell functions, ranging from cell division and chromatin remodeling to vesicle trafficking and maintenance of cellular structure. In fact, mislocalization of actin to cell junctions during development leads t...    Read more.
Understanding Actin Alpha 2 Smooth Muscle
Actins are extremely highly conserved structural proteins found in all eukaryotic cell cytoskeletons that govern cell structure, movement, and shape integrity. Six distinct actin isoforms, each encoded by a different gene and developmentally-regulated...    Read more.
Read more alpha-Smooth Muscle Actin related blogs.