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Oxidative Stress

Tired T cells: Hypoxia Drives T cell Exhaustion in the Tumor Microenvironment

Banner image showing cancer cells in hypoxic conditions.

By Hunter Martinez

Tags: 
Adaptive Immunity
Hypoxia
immunology
metabolism
Mitochondria
Oxygen
ROS
T Cells
T cell exhaustion
T cell receptor
Tumor Microenvironment
BLIMP1/PRDM1
CD8
HIF-1 alpha
IFN-gamma
LAG-3
NFAT
NGFI-B alpha/Nur77/NR4A1
PD-1
PGC1 alpha
TIGIT
TNF-alpha
Hunter Martinez

Using CometChip to Characterize Extracellular Regulators of DNA Repair: Does CD73 Levels in Cancer Cells Affect DNA Repair by Regulating Levels of Intracellular NAD+?

3D rendering of CometChip as a banner image.

By Natalia Gurule, PhD

 

Tags: 
Base Excision Repair
Cancer
CometAssay
CometChip
DNA Damage
DNA Repair
Metabolic Signaling
Tumor Microenvironment
TME
5’Nucleotidase/CD73
CD73
Nicotinamide Adenine Dinucleotide
NAD
PARP
Natalia Gurule

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress

Immunocytochemical staining of formalin-fixed, permeabilized PC12 cells with rabbit polyclonal DRP1 antibody and detected with Dylight 488 (green) and the nuclei counterstained with DAPI (blue).

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
HIV
Human Immunodeficiency Virus
Mitochondria
Mitophagy
ROS
Oxidative Stress
GP120
Tat
Methamphetamine
neurodegeneration
Neurons
LC3B
p62
Autophagy
MAP2
DRP1
Antioxidants
Jamshed Arslan