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Immunotherapy

Hypoxia-Dependent CAR Stabilizing Construct in T cells Improves Solid Tumor Targeting and Efficacy

Banner image showing a chimeric antigen receptor (CAR) T cell.

By Victoria Osinski, PhD

Tags: 
Cancer
Chimeric Antigen Receptor
CAR-T
Hypoxia
immunology
Immunotherapy
Oxygen
T Cells
Tumor
Tumor Microenvironment
EGFR
ErbB2/Her2
ErbB3/Her3
ErbB4/Her4
HIF-1 alpha
Victoria Osinski

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

Tags: 
Bacteria
Cancer
Cancer Research
Checkpoint Blockade
Checkpoint Inhibitors
immunology
Immuno-oncology
Immunotherapy
Innate Immunity
L-arginine
T Cells
Tumor
ARG-2
CD4
CD8
PD-1
PD-L1
Jamshed Arslan

Immune Cell Metabolic Flux Influences Type I Diabetes

Banner image showing mitochondrion and metabolic pathways and targets, from Tocris.

By Hunter Martinez

Tags: 
Adaptive Immunity
Diabetes
Type I Diabetes
Immunometabolism
Innate Immunity
Macrophage
metabolism
Mitochondria
mTOR Pathway
T Cells
ACSL1
CD4
COX-2
IL-1 beta/IL-1F2
IL-12
IL-18/IL-1F4
Insulin
MHC class II
PGE2
TNF-alpha
Hunter Martinez

Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy

Banner image showing the workflow for Natural Killer (NK) cells.

By Victoria Osinski, PhD

Tags: 
Natural Killer Cell
NK Cell
Cancer
immunology
Immuno-oncology
Immunotherapy
CD8
MHC Class I
NKG2A/CD159a/KLRC1
NKG2C/CD159c/KLRC2
NKG2D/CD314
NKG2E/KLRC3
KLRC4
NKG2H
DAP12
Killer Cell Immunoglobulin-like Receptor
CD7
CD19
Siglec-3/CD33
MUC1
ErbB2/Her2
MICA
MICB
ULBP
HDAC
HLA G
KIR2DL4/CD158d
Victoria Osinski