Atg10

Animal Models to Study Autophagy

By Christina Towers, PhD

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Christina Towers

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From Then ‘till Now: The History of Autophagy and Cancer Research

By Christina Towers, PhD.

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Tat-Beclin peptide

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ATG12 - a ubiquitin-like protein essential for autophagosome assembly

Atg12 is a ubiquitin-like protein that plays an essential role in cellular homeostasis by regulating the degradation and recycling of cytoplasmic organelles and macromolecules. Atg12 is one of two ubiquitin-like protein systems that is required during the early steps of autophagosome formation. Upon the initiation of phagopore assembly Atg12 is activated by binding to the E1-like enzyme Atg7 and is then transferred to the E2 enzyme Atg10.

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