Antibodies

This is not a joke, these proteins with funny names actually do exist. View our list of six proteins with funny and unusual names including: Bambi, Yippee-like 3, Wee1, SPAM1, SPOCK1 and Bagpipe homeobox protein homolog 1. Learn more about their function and molecular weight. Do you have a funny protein name not included on the list? Submit a name in the comment section to let us know which ones should be included in our next infographic.  

The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is essential for cancer progression because it governs many downstream molecules that control cellular growth and development. The effects of NFkB on angiogenic pathways and cell response mechanisms to stress and damage are well established in the literature.

The Dnmt1 enzyme is a member of the C5-methyltransferase family responsible for repairing cytosines in double-stranded DNA (dsDNA). This enzyme uses a nucleophilic attack mechanism and is the most abundantly found mammalian DNA methyltransferase. It primarily acts upon CpG residues and prefers hemimethylated residues, but can also methylating unmethylated DNA. The cell relies upon Dnmt1 as its key methylation maintenance enzyme both for DNA replication and repair as well as for de novo methylation during somatic cell development and differentiation.

The D4-GDI protein is a negative regulator of the Ras-related Rho family of small molecule "molecular switch" GTPases. The Rho GTPases modify cell structure and architecture via rapid changes to the actin cytoskeleton and cell membrane. Many of these physiological processes are associated with apoptotic cell death, thus the in vivo removal of D4-GDI inhibitory block is critical for proper induction and progression of apoptosis in cells.

Chemokines play a central role in inflammation and are crucial for recruitment of immune cells to sites of infection. The chemokine-dependent activation of leukocytes occurs through binding to G-protein coupled receptors. These chemokine receptor subtypes can be divided into two major groups, CXCR and CCR.

FIH-1/HIF-1AN (factor inhibiting hypoxia-inducible factor-1/ HIF1AN) is a 40.3kDa protein which is expressed as asparaginyl hydroxylase enzyme in various multicellular organisms from worms/flies to mouse/rat and human beings.

The unfolded protein response (UPR) is a eukaryotic cell process that addresses ER stress. UPR is initiated by three ER-localized sensors: PKR-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 alpha (IRE1 alpha). UPR-downstream signaling is modulated by the ATF6 and IRE1-XBP1 pathways.

Autophagy, a protein degradation process through autophagosome-lysosomal pathway, is important for cellular homeostasis and plays a role in many diseases. To help researchers learn more about this process and the products available for its study, Novus Biologicals has released a new Autophagy catalog.

Western blotting (or immunoblotting) is a widely used procedure to detect specific proteins in tissues and cell extracts and the Blue Marker Antibody can help make it easier and more accurate to size proteins of interest.  The Blue Marker Antibody (6F4-F6) is a unique monoclonal antibody that binds to and recognizes prestained blue dye molecular weight standards from different vendors.

Carbonic anhydrase IX is a member of the carbonic anhydrase family. This family consists of catalytic enzymes capable of converting carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. This family of molecules is abundantly expressed in all mammalian tissues and helps to govern the pH in normal tissues. CAIX is very stable and found in the membrane. It is also one of the most hypoxically-inducible genes, thus establishing its application as a reliable and consistent hypoxia histochemical marker.