IkB kinase

The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is essential for cancer progression because it governs many downstream molecules that control cellular growth and development. The effects of NFkB on angiogenic pathways and cell response mechanisms to stress and damage are well established in the literature.