TRANCE/TNFSF11/RANK L Products

Description

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]

Bioinformatics

Uniprot	ENSP00000351347 Human
Product By Gene ID	8600
Alternate Names	CD254 antigen CD254 ODF OPGL OPGLOPTB2 Osteoclast differentiation factor Osteoprotegerin ligand RANK L RANKL RANKLreceptor activator of nuclear factor kappa B ligand Receptor activator of nuclear factor kappa-B ligand sOdf TNF-related activation-induced cytokine TNFSF11 TRANCE TRANCEODFhRANKL2 tumor necrosis factor (ligand) superfamily, member 11 tumor necrosis factor ligand superfamily member 11

Research Areas for TRANCE/TNFSF11/RANK L

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Cancer

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The diverse functions of RANKL/TRANCE/TNFSF11 RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...    Read more.

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