WFS1 Antibody (1057230) [DyLight 680]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 1057230
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 680

WFS1 Antibody (1057230) [DyLight 680] Summary

• Immunogen: E. coli derived recombinant human WFS1
  Arg653-Phe783
  Accession # O76024
• Specificity: Detects human WFS1 in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for WFS1 Antibody (1057230) [DyLight 680]

• DFNA14
• DFNA38
• DFNA6
• DIDMOAD
• FLJ51211
• WFRS
• WFS1
• WFSwolframin
• Wolfram syndrome 1 (wolframin)
• Wolframin

Background

Wolframin (WFS1) is a multipass endoplasmic reticulum (ER) membrane protein that plays an important role in maintaining homeostasis of the ER in the pancreas. WFS1 helps to regulate cellular calcium cation homeostasis by altering the filling state of the ER calcium cation store.

WFS1 is the major component of Wolfram syndrome, a rare form of juvenile diabetes, also known as diabetes insipidus and mellitus with optic atrophy and deafness syndrome (DIDMOAD). WFS1 is normally up-regulated during insulin secretion, and inactivation of the protein causes ER stress. In turn, chronic ER stress is thought to play a major role in Wolfram syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.