WFS1 Products

Antibodies
WFS1 Antibody
WFS1 Antibody
AF7417
Species: Hu
Applications: WB
Host: Sheep Polyclonal
WFS1 Antibody
WFS1 Antibody
NBP1-84265
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
WFS1 Overexpression Lysate (N ...
WFS1 Overexpression Lysate (Native)
NBL1-17845
Applications: WB
WFS1 Overexpression Lysate (N ...
WFS1 Overexpression Lysate (Native)
NBP2-09765
Applications: WB
Proteins
WFS1 Recombinant Protein Anti ...
WFS1 Recombinant Protein Antigen
NBP1-84265PEP
Species: Hu
Applications: AC

Description

Wolframin (WFS1) is a multipass endoplasmic reticulum (ER) membrane protein that plays an important role in maintaining homeostasis of the ER in the pancreas. WFS1 helps to regulate cellular calcium cation homeostasis by altering the filling state of the ER calcium cation store.

WFS1 is the major component of Wolfram syndrome, a rare form of juvenile diabetes, also known as diabetes insipidus and mellitus with optic atrophy and deafness syndrome (DIDMOAD). WFS1 is normally up-regulated during insulin secretion, and inactivation of the protein causes ER stress. In turn, chronic ER stress is thought to play a major role in Wolfram syndrome.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Product By Gene ID 7466
Alternate Names
  • DFNA6
  • FLJ51211
  • DFNA38
  • DIDMOAD
  • DFNA14
  • WFRS
  • WFSwolframin
  • Wolfram syndrome 1 (wolframin)

Research Areas for WFS1

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
ER Markers
Lipid and Metabolism
Neuroscience
Sensory Systems
Signal Transduction
Vision

PTMs for WFS1

Learn more about PTMs related to WFS1.

Phosphorylation
Glycosylation
Ubiquitination
Cleavage

Bioinformatics Tool for WFS1

Discover related pathways, diseases and genes to WFS1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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