WFS1 Products

Description

Wolframin (WFS1) is a multipass endoplasmic reticulum (ER) membrane protein that plays an important role in maintaining homeostasis of the ER in the pancreas. WFS1 helps to regulate cellular calcium cation homeostasis by altering the filling state of the ER calcium cation store.

WFS1 is the major component of Wolfram syndrome, a rare form of juvenile diabetes, also known as diabetes insipidus and mellitus with optic atrophy and deafness syndrome (DIDMOAD). WFS1 is normally up-regulated during insulin secretion, and inactivation of the protein causes ER stress. In turn, chronic ER stress is thought to play a major role in Wolfram syndrome.

Bioinformatics

Entrez	7466 Human 83725 Rat
Uniprot	NM_006005 Human NP_001139325 Human O76024 Human
Product By Gene ID	7466
Alternate Names	DFNA14 DFNA38 DFNA6 DIDMOAD FLJ51211 WFRS WFSwolframin Wolfram syndrome 1 (wolframin)

Research Areas for WFS1

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
ER Markers
Lipid and Metabolism
Neuroscience
Sensory Systems
Signal Transduction
Vision