Vanilloid R1/TRPV1 Antibody [DyLight 650]

• Reactivity: Hu, Mu, Rt, In, Pm
• Applications: WB, ICC/IF, ICC/IF, IHC (-)
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

Vanilloid R1/TRPV1 Antibody [DyLight 650] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: A synthetic peptide made to an N-terminal portion of the rat TRPV1 protein (between residues 1-50) [Uniprot: O35433]
• Localization: Multi-pass membrane protein. Note: Mostly, but not exclusively expressed in post-synaptic dendritic spines.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TRPV1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunofluorescence
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-97417. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Reactive to Octopus vulgaris.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Vanilloid R1/TRPV1 Antibody [DyLight 650]

• Capsaicin Receptor
• Osm-9-like TRP channel 1
• OTRPC1
• transient receptor potential cation channel subfamily V member 1
• transient receptor potential cation channel, subfamily V, member 1
• transient receptor potential vanilloid 1a
• transient receptor potential vanilloid 1b
• TRPV1
• Vanilloid R1
• Vanilloid receptor 1
• vanilloid receptor subtype 1
• VanilloidR1
• VR1
• VR1DKFZp434K0220

Background

TRPV1 (transient receptor potential cation channel subfamily V member 1, capsaicin receptor, vanilloid receptor, Vr1) is a polymodal nociceptor activated by heat, vanilloids (capsaicin), and protons. It is primarily expressed in the dorsal root ganglia and peripheral nerve endings. TRPV1 antagonists are a potential therapeutic target for many suffering chronic physical and neuropathic pain. However, due to its other role in the regulation of body temperature, these therapies are currently experiencing a barrier. On the other hand, TRPV1 agonists can be used to desensitize nerves after activation, thereby reducing pain. The research around TRPV1 is broad, where it is studied in fields such as anxiety, pain, oxidative stress, taste, inflammation, depression, respiratory disease, and various psychiatric disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRPV1