Vanilloid R1/TRPV1 Antibody

• Reactivity: Rb
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated
• Concentration: LYOPH

Vanilloid R1/TRPV1 Antibody Summary

• Immunogen: A synthetic peptide from amino acid region 600-650 of rabbit Vanilloid R1/TRPV1 conjugated to an immunogenic carrier protein was used as the antigen.
• Clonality: Polyclonal
• Host: Sheep
• Gene: TRPV1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:300-1:2000
  • Western Blot 1:300-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Alternate Names for Vanilloid R1/TRPV1 Antibody

• Capsaicin Receptor
• Osm-9-like TRP channel 1
• OTRPC1
• transient receptor potential cation channel subfamily V member 1
• transient receptor potential cation channel, subfamily V, member 1
• transient receptor potential vanilloid 1a
• transient receptor potential vanilloid 1b
• TRPV1
• Vanilloid R1
• Vanilloid receptor 1
• vanilloid receptor subtype 1
• VanilloidR1
• VR1
• VR1DKFZp434K0220

Background

FUNCTION: Receptor-activated non-selective calcium permanent cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Vanilloid R1/TRPV1 Antibody (NB100-98890)(1)

Publication using NB100-98890

• Martinez-Garcia MC, Martinez T, Paneda C et al. Differential expression and localization of transient receptor potential vanilloid 1 in rabbit and human eyes. Histol Histopathol 2013-11-01 [PMID: 23709255] (IF/IHC)

FAQs for Vanilloid R1/TRPV1 Antibody (NB100-98890). (Showing 1 - 1 of 1 FAQ).

1. We are working with your antibody ant-TRPV1 (NB100-98890). To test our results we would like to know if the blocking peptide is available.
   • Unfortunately we do not sell the blocking peptide for this antibody.

Bioinformatics

• Gene Symbol: TRPV1
• Entrez:
  • 100008926(Rabbit)
• Uniprot:
  • Q6RX08(Rabbit)