USP22 Antibody [DyLight 488]

• Reactivity: Hu, Mu
• Applications: WB, ChIP, Func, GS, IHC, ChIP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 488

USP22 Antibody [DyLight 488] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: A genomic peptide made to an internal region of the human USP22 protein (within residues 100-205). [Swiss-Prot Q9H3R0]
• Localization: Nucleus.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: USP22
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP)
  • Chromatin Immunoprecipitation
  • Gel Super Shift Assays
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Proximity Ligation Assay
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-49644. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for USP22 Antibody [DyLight 488]

• Deubiquitinating enzyme 22
• EC 3.1.2.15
• EC 3.4.19.12
• KIAA1063ubiquitin carboxyl-terminal hydrolase 22
• KIAA1064
• ubiquitin specific peptidase 22
• ubiquitin specific peptidase 3-like
• ubiquitin specific protease 22
• Ubiquitin Thioesterase 22
• Ubiquitin thiolesterase 22
• ubiquitin-specific processing protease 22
• Ubiquitin-specific-processing protease 22
• USP22
• USP3L

Background

USP22 is the component of the histone acetylation complex, SAGA, that acts as a deubiquinating enzyme. It is a cofactor for gene promoters like MYC. Depleting USP22 prevents MYC from controlling the transcription and expression of thousands of other genes. Therefore, it can be postulated that USP22 is the critical mediator of MYC induced oncogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: USP22