UBR5/EDD Antibody [Alexa Fluor™ Plus 405]

Product Discontinued

UBR5/EDD Antibody [Alexa Fluor™ Plus 405] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 600 and 650 of human E3 Ubiquitin Protein Ligase, HECTdomain containing, 1 using the numbering given in entry NP_056986.2 (GeneID 51366)
• Localization: Nucleus
• Predicted Species: Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: UBR5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Knockdown Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for UBR5/EDD Antibody [Alexa Fluor™ Plus 405]

• DD5
• E3 ubiquitin protein ligase, HECT domain containing, 1
• E3 ubiquitin-protein ligase, HECT domain-containing 1
• EC 6.3.2
• EC 6.3.2.-
• EDD
• EDD1
• EDD1E3 ubiquitin-protein ligase UBR5
• EDDE3 identified by differential display
• hHYD
• HYD
• HYDFLJ11310
• Hyperplastic discs protein homolog
• KIAA0896MGC57263
• progestin induced protein
• Progestin-induced protein
• ubiquitin protein ligase E3 component n-recognin 5
• ubiquitin-protein ligase
• UBR5

Background

EDD encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UBR5