Tyk2 Antibody (8G8B3)

Images

 
Western Blot: Tyk2 Antibody (8G9H5) [NB110-89454] - Figure 1: Western blot analysis using TYK2 mouse mAb against truncated TYK2 recombinant protein (1) and Jurkat cell lysate(2).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC
Clone
8G8B3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Tyk2 Antibody (8G8B3) Summary

Immunogen
Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3)
Specificity
TYK2 (8G8B3)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TYK2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:10000
  • Immunohistochemistry 1:200 - 1:1000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.03% Sodium Azide
Purity
Unpurified

Alternate Names for Tyk2 Antibody (8G8B3)

  • EC 2.7.10
  • EC 2.7.10.2
  • JTK1
  • non-receptor tyrosine-protein kinase TYK2
  • Tyk2
  • tyrosine kinase 2

Background

Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TYK2
Entrez