Tyk2 Antibody (307214) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clone: 307214
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Tyk2 Antibody (307214) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human Tyk2
  Pro2-Leu51
  Accession # P29597
• Specificity: Detects human Tyk2 in Western blots.
• Isotype: IgG3
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tyk2 Antibody (307214) [Alexa Fluor® 700]

• EC 2.7.10
• EC 2.7.10.2
• JTK1
• non-receptor tyrosine-protein kinase TYK2
• Tyk2
• tyrosine kinase 2

Background

Tyk2 belongs to the Janus family of intracellular tyrosine kinases that are activated by receptors for many cytokines. Activation of Tyk2 occurs via phosphorylation at two adjacent tyrosine residues, Y1054 and Y1055, within the kinase domain. Tyk2 is required for interferon beta -mediated tyrosine phosphorylation of STAT3 and interferon receptor 1. Mice lacking Tyk2 are susceptible to parasitic infection but resistant to autoimmune arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.