Rat and mouse reactivity reported in scientific literature. Please see Publications tab for full list. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS (pH 7.4), 0.2% BSA, Tween-20
0.05% Sodium Azide
Protein A or G purified
Alternate Names for Tryptase alpha/TPS1 Antibody (AA1)
tryptase alpha/beta 1
Principal Names: Tryptase alpha/beta 1 Official Gene Symbol: TPSAB1 Gene ID: 7177 (Human) Gene Map Locus: 16p13.3 (Human). Human tryptases are divided into two groups, alpha and beta. beta-Tryptase appears to be the major type stored in mast cell secretory granules and alpha-tryptase is the major isoform expressed by basophils.beta-tryptase, a major constituent of mast cell secretory granules, has emerged recently as the most specific marker in vivo of mast cell activation in humans. It is a trypsin like serine protease that hydrolyzes peptide bonds on the C-terminal side of basic amino acids. Unlike trypsin, however, it is highly selective in hydrolyzing its peptide and protein targets and resists inactivation by circulating inhibitors. It has potential roles in the lung, skin, and other tissues as a local anticoagulant, activator of collagenase, promoter of smooth muscle contraction, and modulator of neuropeptide activity. The pathogenic role for tryptases has been observed in asthmatic airway inflammation other inflammatory disorders. The gene is mapped on human chromosome 16p13.3.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Maiese A, Scopetti M, Santurro A et al. Corpse dismemberment: A case series. Solving the puzzle through an integrated multidisciplinary approach Journal of Forensic and Legal Medicine Jan 1 2020 (IHC, Human)
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