TRIB2 Antibody

Immunohistochemistry-Paraffin: TRIB2 Antibody [NBP1-52474] - Analysis of anti-TRIB2 antibody with human colon at concentration 3.75 ug/ml.

Immunohistochemistry-Paraffin: TRIB2 Antibody [NBP1-52474] - Analysis of anti-TRIB2 antibody with human spleen at concentration 3.75 ug/ml.

Product Discontinued

TRIB2 Antibody Summary

• Immunogen: Synthetic peptide from human TRIB2.
• Specificity: Human TRIB2.
• Predicted Species: Orangutan (100%), Turkey (92%), Chicken (92%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TRIB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 3.75 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Opossum (85%).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: TBS (pH 7.3) and 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TRIB2 Antibody

• C5FW
• FLJ57420
• GS3955
• TRB-2
• TRB2tribbles homolog 2
• tribbles homolog 2 (Drosophila)

Background

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRIB2
• Entrez:
  • 28951(Human)
• Uniprot:
  • Q92519(Human)