TRBP Antibody (PCRP-TARBP2-1E5) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF, MA
• Clone: PCRP-TARBP2-1E5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

TRBP Antibody (PCRP-TARBP2-1E5) [Alexa Fluor™ Plus 647] Summary

• Immunogen: Recombinant full-length human TRBP protein (Uniprot: Q15633)
• Localization: Cytoplasm, Cytoplasm > perinuclear region. Nucleus
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: TARBP2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Protein Array
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TRBP Antibody (PCRP-TARBP2-1E5) [Alexa Fluor™ Plus 647]

• LOQS
• RISC-loading complex subunit TARBP2
• TAR (HIV) RNA binding protein 2
• TAR (HIV) RNA-binding protein 2
• TAR (HIV) RNA-binding protein TRBP1
• TAR (HIV-1) RNA binding protein 2
• TAR RNA binding protein 2
• TAR RNA-binding protein 2
• trans-activation responsive RNA-binding protein
• Trans-activation-responsive RNA-binding protein
• TRBP
• TRBP1
• TRBP2

Background

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TARBP2