Immunocytochemistry/ Immunofluorescence: TP53INP2 Antibody [NBP1-71704] - TP53INP2 antibody was tested at 1:200 in HeLa cells with FITC (green). Nuclei and actin were counterstained with Dapi (blue) and Phalloidin (red).
Immunohistochemistry: TP53INP2 Antibody [NBP1-71704] - Staining of TP53INP2 in mouse prostate.
Human and mouse. Immunogen has 81% identity to rat.
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Alternate Names for TP53INP2 Antibody
chromosome 20 open reading frame 110
diabetes and obesity regulated
p53-inducible protein U
tumor protein p53 inducible nuclear protein 2
tumor protein p53-inducible nuclear protein 2
Tumor protein p53 inducible nuclear protein 2 is necessary for tumor cell invasive migration. Different splicing events in formation of this protein are key determinants of whether the tumor cell invasive morphology exists, and is probably mediated through a Golgi complex interaction. TP53INP2 also binds the Atg8-like proteins and VMP1 during autophagy, and generates scaffolding for autophagosome membranes. LC3 and LC3R also interact with TP53INP2 through an interaction with the autophagosome transmembrane protein VMP1. Thus, the effect of TP53INP2 on tumor growth seems to be both a direct effect on invasion and an indirect effect of insufficient autophagosome scaffolding and inflammation events in response to tumor formation.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.