TOR/mTOR Antibody (834115) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 834115
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 750

TOR/mTOR Antibody (834115) [Alexa Fluor® 750] Summary

• Immunogen: Phosphopeptide containing the human TOR S2448 site
  Accession # P42345
• Specificity: Detects human Phospho-TOR (S2448) in ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TOR/mTOR Antibody (834115) [Alexa Fluor® 750]

• EC 2.7.11.1
• FK506 binding protein 12-rapamycin associated protein 1
• FK506 binding protein 12-rapamycin associated protein 2
• FK506-binding protein 12-rapamycin complex-associated protein 1
• FKBP12-rapamycin complex-associated protein
• FLJ44809
• FRAP
• FRAP1
• FRAP1FKBP12-rapamycin complex-associated protein 1
• FRAP2
• Mammalian target of rapamycin
• mechanistic target of rapamycin (serine/threonine kinase)
• Mechanistic target of rapamycin
• MTOR
• RAFT1
• rapamycin and FKBP12 target 1
• rapamycin associated protein FRAP2
• Rapamycin target protein 1
• RAPT1FKBP-rapamycin associated protein
• serine/threonine-protein kinase mTOR
• TOR

Background

The mammalian Target of Rapamycin (mTOR) is a member of the PI 3-kinase-related kinase (PIKK) family. mTOR is the protein target of rapamycin, an anti-rejection drug used in transplantation and promising anti-cancer agent. Recent evidence suggests that mTOR is phosphorylated at S2448 by the S6 protein kinase 1 (S6K1) (1, 2), rather than a direct phosphorylation by the Akt protein kinase. This S2448 phosphorylation activates mTOR to affect the downstream control of cell growth and survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.