Thromboxane A2 R/TBXA2R Antibody

Immunohistochemistry-Paraffin: Thromboxane A2 R/TBXA2R Antibody [NLS1278] - Analysis of anti-TBXA2R antibody with human uterus, endometrium at 4 ug/ml.

Product Discontinued

Thromboxane A2 R/TBXA2R Antibody Summary

• Immunogen: Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human Thromboxane A2 R/TBXA2R.
• Specificity: Human TBXA2R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Canine (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TBXA2R
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 4 ug/ml
• Control:

  Thromboxane A2 R/TBXA2R Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Bat (85%), Bovine (85%), Porcine (85%), Opossum (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Thromboxane A2 R/TBXA2R Antibody

• BDPLT13
• Prostanoid TP Receptor
• TBXA2R
• Thromboxane A2 R
• thromboxane A2 receptor
• Thromboxane A2R
• TP
• TXA2-R
• TXA2R2

Background

The thromboxane A2 receptor (TBXA2R) is a member of the Prostanoid Receptor subfamily. TBXA2R performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 has been implicated in myocardial infarct, stroke, and asthma. Additionally, thromboxane-prostanoid receptors have been implicated in the pathogenesis of cardiovascular diseases. Changes in TBXA2R function have also been linked to a hereditary bleeding disorder. The thromboxane A2 receptor is encoded by a single gene that is alternatively spliced at the carboxyl terminus, resulting in two variants, TP (343 residues) and TP (407 residues) that share the first 328 amino acids. TBXA2R expression has been documented in blood, brain, eye, kidney, nose, placenta, uterus, and vessel. ESTs have been isolated from brain, kidney, placenta, and thymus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TBXA2R
• Entrez:
  • 6915(Human)