TfR2 Antibody (JG58-34)

Western Blot: TfR2 Antibody (JG58-34) [NBP2-89122] - Analysis of Transferrin Receptor 2 on HepG2 cell using anti-Transferrin Receptor 2 antibody at 1/1,000 dilution.

Immunohistochemistry-Paraffin: TfR2 Antibody (JG58-34) [NBP2-89122] - Analysis of paraffin-embedded human liver cancer tissue using anti-Transferrin Receptor 2 antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: TfR2 Antibody (JG58-34) [NBP2-89122] - Analysis of paraffin-embedded human liver tissue using anti-Transferrin Receptor 2 antibody. Counter stained with hematoxylin.

Product Discontinued

TfR2 Antibody (JG58-34) Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant protein within Human TfR2 aa 130-320 / 801. (SwissProt: Q9UP52 Human)
• Localization: Cell membrane. Cytoplasm.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TFR2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:2000
• Theoretical MW: 89 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for TfR2 Antibody (JG58-34)

• HFE3
• HFE3transferrin receptor protein 2
• MGC126368
• TfR2
• TFRC2
• transferrin receptor 2

Background

TFR2 is a gene that codes for a protein with three isoforms, with lengths of 801, 630, and 774 amino acids and weights of approximately 89, 70, and 86 kDa respectively. TFR2 helps in the cellular uptake of transferrin-bound iron as well as iron metabolism, erythrocyte differentiation, and hepatocyte function. Current studies are being done on several diseases and disorders related to this gene including porphyria cutanea tarda, iron overload, beta thalassemia, liver cirrhosis, hepatitis C, fatty liver disease, leukemia, lymphoma, liver disease, and cystic fibrosis. TRF2 has also been shown to have interactions with HFE, TF, UBC, and SOCS3 in pathways such as the AMPK enzyme complex and iron metabolism in the placenta pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TFR2