TfR (Transferrin R) Antibody (ER-MP21)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, Func, IHC, IHC-Fr
Clone
ER-MP21
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
0.1 mg/ml

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Catalog# & Conjugate Size Price

TfR (Transferrin R) Antibody (ER-MP21) Summary

Immunogen
ER-MP21 recognizes CD71, the transferrin receptor 1.
Marker
Recycling Endosome Marker
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
TFRC
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Functional
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
This product works in Flow Cytometry, Functional and Immunohistochemistry-Frozen. Not recommended in Immunohistochemistry- Paraffin.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for TfR (Transferrin R) Antibody (ER-MP21)

  • CD71 antigen
  • CD71
  • CD71TRFR
  • p90
  • T9
  • TfR (Transferrin R)
  • TfR (TransferrinR)
  • TfR
  • TFR1
  • TFRC
  • TR
  • transferrin receptor (p90, CD71)
  • transferrin receptor protein 1
  • TRFR

Background

The monoclonal antibody ER-MP21 recognizes CD71, the transferrin receptor 1. CD71 is a 200 kDa glycoprotein composed of two identical, disulfide-linked chains. Each chain is capable of binding transferrin, an iron-transport molecule. Binding of transferrin to its receptor followed by endocytosis of the receptor-ligand complex is a major cellular iron-uptake mechanism. Iron uptake by the proliferating cell is essential for the iron-containing enzyme ribonucleotide reductase involved with DNA synthesis. CD71 is not only expressed by cycling cells, but also by cells that require iron for other iron-dependent proteins, such as the enzyme peroxidase in monocytes. Rapidly proliferating cells, as in malignancy, generally express CD71 abundantly. Furthermore, CD71 has been described as a marker of immature, proliferating T cells. The monoclonal antibody ER-MP21 inhibits proliferation and differentiation during early T cell development. ER-MP21 recognizes murine CD71, but does not compete with transferrin binding.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for TfR (Transferrin R) Antibody (NBP1-51810). (Showing 1 - 1 of 1 FAQ).

  1. Does the Transferrin Receptor Antibody (ER-MP21) have reactivity to the human transferrin receptor? Could you please tell me if the Ab epitope is localized in the N- or C-terminal of the protein?
    • Our product NBP1-51810 was made to the full length mouse protein sequence. We have not yet epitope mapped this product, so we do not know which region the antibody will bind to.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

FITC Labeled NBP1-49604

Additional TfR (Transferrin R) Products

Bioinformatics Tool for TfR (Transferrin R) Antibody (NBP1-51810)

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Diseases for TfR (Transferrin R) Antibody (NBP1-51810)

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PTMs for TfR (Transferrin R) Antibody (NBP1-51810)

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Research Areas for TfR (Transferrin R) Antibody (NBP1-51810)

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Blogs on TfR (Transferrin R).

Transferrin and the blood brain barrier
Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...  Read full blog post.

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Bioinformatics

Gene Symbol TFRC
Entrez