TEM4 Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC
• Concentration: 0.2 mg/ml

TEM4 Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 18 amino acids near the center of human TEM4.

  Source: Synthetic

  (Accession #: Q96PE2)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: ARHGEF17
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-77314.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for TEM4 Antibody Blocking Peptide

• 164 kDa Rho-specific guanine-nucleotide exchange factor
• FLJ90019
• KIAA0337P164RHOGEF
• p164RhoGEF
• p164-RhoGEFRho-specific guanine-nucleotide exchange factor 164 kDa
• Rho guanine nucleotide exchange factor (GEF) 17
• TEM4rho guanine nucleotide exchange factor 17
• Tumor endothelial marker 4

Background

TEM4 (Tumor endothelial marker 4) is a Rho-specific GEF (guanine-nucleotide exchange factor) with novel structural and regulatory properties and predominant expression in the heart. Rho GTPases, which are activated by specific GEFs, play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful as a target, therapeutically.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ARHGEF17