TEM4 Products

TEM4 Antibody
TEM4 Antibody
Species: Hu, Mu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
TEM4 Antibody
TEM4 Antibody
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TEM4 Recombinant Protein Anti ...
TEM4 Recombinant Protein Antigen
Species: Hu
Applications: AC
TEM4 Antibody Blocking Peptid ...
TEM4 Antibody Blocking Peptide
Species: Hu
Applications: AC


TEM4 (Tumor endothelial marker 4) is a Rho-specific GEF (guanine-nucleotide exchange factor) with novel structural and regulatory properties and predominant expression in the heart. Rho GTPases, which are activated by specific GEFs, play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful as a target, therapeutically.


Entrez Human
Uniprot Human
Product By Gene ID 9828
Alternate Names
  • 164 kDa Rho-specific guanine-nucleotide exchange factor
  • p164RhoGEF
  • Tumor endothelial marker 4
  • p164-RhoGEFRho-specific guanine-nucleotide exchange factor 164 kDa
  • TEM4rho guanine nucleotide exchange factor 17
  • KIAA0337P164RHOGEF
  • FLJ90019
  • Rho guanine nucleotide exchange factor (GEF) 17

Pathways for TEM4

View related products by pathway and learn more about each of the pathways below.

Mismatch Repair

PTMs for TEM4

Learn more about PTMs related to TEM4.


Bioinformatics Tool for TEM4

Discover related pathways, diseases and genes to TEM4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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