WB, ELISA, IHC, IHC-PHost:
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TEM4 (Tumor endothelial marker 4) is a Rho-specific GEF (guanine-nucleotide exchange factor) with novel structural and regulatory properties and predominant expression in the heart. Rho GTPases, which are activated by specific GEFs, play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful as a target, therapeutically.
|Product By Gene ID
- 164 kDa Rho-specific guanine-nucleotide exchange factor
- Tumor endothelial marker 4
- p164-RhoGEFRho-specific guanine-nucleotide exchange factor 164 kDa
- TEM4rho guanine nucleotide exchange factor 17
- Rho guanine nucleotide exchange factor (GEF) 17
PTMs for TEM4
Learn more about PTMs related to TEM4.Ribosylation
Bioinformatics Tool for TEM4
Discover related pathways, diseases and genes to TEM4. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.