TDAG8/GPR65 Antibody (976128) [FITC]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 976128
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: FITC

TDAG8/GPR65 Antibody (976128) [FITC] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human TDAG8/GPR65
  Met1-Glu337
  Accession # Q8IYL9
• Specificity: Detects human TDAG8/GPR65 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for TDAG8/GPR65 Antibody (976128) [FITC]

• G protein-coupled receptor 65
• GPR65
• G-protein coupled receptor 65
• Psychosine Receptor
• T-cell death-associated gene 8 protein
• TDAG8
• TDAG8hTDAG8

Background

GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. GPR65 has been reported in human in peripheral blood leukocytes, spleen, lymph node, and thymus. ESTs have been isolated from human B-cell/lung/testis, brain/lung/testis, pancreas/spleen, lung/spleen, leukocyte, embryo, kidney, liver/spleen, thyroid, and vessel libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.