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GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. GPR65 has been reported in human in peripheral blood leukocytes, spleen, lymph node, and thymus. ESTs have been isolated from human B-cell/lung/testis, brain/lung/testis, pancreas/spleen, lung/spleen, leukocyte, embryo, kidney, liver/spleen, thyroid, and vessel libraries.
![Western Blot TDAG8/GPR65 Antibody (976128) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/TDAG8_MAB10077_Western_Blot_23092.jpg)
![Immunocytochemistry TDAG8/GPR65 Antibody (976128) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab10077_human-tdag8-gpr65-mab-clone-976128-immunocytochemistry-32202111118.jpg)
