TAPP1/PLEKHA1 Antibody (376409) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB
• Clone: 376409
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 350

TAPP1/PLEKHA1 Antibody (376409) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human TAPP1
  Pro2-Val404
  Accession # Q9HB21
• Specificity: Detects human TAPP1 in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TAPP1/PLEKHA1 Antibody (376409) [Alexa Fluor® 350]

• family A (phosphoinositide bindingspecific) member 1
• PH domain-containing family A member 1
• pleckstrin homology domain containing, family A (phosphoinositide bindingspecific) member 1
• PLEKHA1
• TAPP1

Background

TAPP1, gene name PLEKHA1 (pleckstrin homology family A, member 1) is a 70‑75 kDa cytoplasmic adaptor protein that is membrane-associated after binding of the phosphoinositide, PtdIns(3,4)P2. The 404 aa human TAPP1 shares 76% aa identity with mouse TAPP1. It is expressed most highly in skeletal muscle, spleen, lung, thymus and placenta. TAPP1 interacts with cytoskeletal syntrophins, colocalizing in membrane ruffles following PDGF treatment in transfected NIH‑3T3 cells. TAPP1 and the related TAPP2 appear to play a role in B and T cell activation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.